Method and apparatus for determining neovascular flow through tissue in a vessel

• US 6,842,639 B1
• Filed: 03/30/2000
• Issued: 01/11/2005
• Est. Priority Date: 10/03/1997
• Status: Expired due to Term

• Current Assignee: Spectranetics Corporation (Koninklijke Philips N.V.)
• Original Assignee: IntraLuminal Therapeutics, Inc. (DSM-Firmenich AG)
• Inventors: Wolfe, Nicholas, Winston, Thomas R., Neet, John M.
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US09/539,015
• Time in Patent Office: 1,748 Days
• Field of Search: 600/342, 600/476, 600/478, 600/479, 600/487, 600/505, 600/585, 356/477, 356/345, 606/2, 606/3, 606/15
• US Class Current: 600/478
• CPC Class Codes: A61B 18/245 for removing obstructions in blood vessels or calculi
• CPC Class Codes: A61B 2017/00057 Light
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/415 the glands, e.g. tonsils, adenoids or thymus
• CPC Class Codes: A61B 5/418 lymph vessels, ducts or nodes
• CPC Class Codes: A61M 25/01 Introducing, guiding, advancing, emplacing or holding catheters A61M25/10 takes precedence
• CPC Class Codes: A61M 25/0105 Steering means as part of the catheter or advancing means; Markers for positioning systems for detection of markers A61B

Abstract

Methods and apparatus for guiding a guide wire through a blood vessel are described. An exemplary embodiment includes a guide wire coupled to an interferometric guidance system. The interferometric guidance system is configured to provide imaging information of the vessel. The guidance system further includes a flow detection circuit for performing Doppler shift analysis to determine the presence of neovascular channels through an obstruction in the vessel. The neovascular fow information is used by the guide wire operator to guide the guide wire through the obstruction.

Claims

1. Apparatus configured to guide a guide wire through body tissue, said apparatus comprising:

a guide wire having a first proximal end and second distal end; and

at least one interferometric guidance system comprising;

a first optic fiber comprising a first end and a second end, said second end coupled to and extending beyond said guide wire distal end; and

a circuit for generating Doppler shift information relating to neovascular flow through the tissue by revealing relative changes in blood flow velocity at the said second end of said first optic fiber, said interferometric guidance system configured for generating interference information from body tissue.

2. Guide wire guiding apparatus in accordance with claim 1 wherein said interferometric system further comprises:

a low coherence illumination source for generating a first light beam;

a beam splitter for splitting the first light beam into a second light beam and a third light beam;

second optic fiber having a first end and a second end, said first optic fiber wrapped around a first piezo electric transducer, said second optic fiber wrapped around a second piezo electric transducer, said first optic fiber coupled to the guide wire so that said second end of said first optic fiber is adjacent said second end of said guide wire;

a fixed reflector on said second optic fiber second end; and

a detecting element communicatively coupled to said first ends of said first and second optic fibers, said detecting element configured to determine interference between a light beam reflected through said first optic fiber and a light beam reflected through said second optic fiber.

3. Guide wire guiding apparatus in accordance with claim 2 wherein said low coherence illumination source comprises a laser.

4. Guide wire guiding apparatus in accordance with claim 2 wherein said low coherence illumination source comprises a superluminescent emitting diode.

5. Guide wire guiding apparatus in accordance with claim 2 wherein said circuit for a generating Doppler shift information comprises:

a broad band filter; and

a frequency-to-voltage converter coupled in series to said broad band filter, wherein said broad band filter is coupled to an output of said detecting element.

6. Guide wire guiding apparatus in accordance with claim 5, wherein said circuit for generating Doppler shift information further comprising an FM detector, said FM detector coupled in series to an output of said broad band filter, and to an input of said frequency-to-voltage converter.

7. Guide wire guiding apparatus in accordance with claim 1 wherein said second end of said first optic fiber is polished flat.

8. Guide wire guiding apparatus in accordance with claim 1 wherein said second end of said first optic fiber is polished at an angle of about 8 degrees relative to a cross-sectional plane orthonormal to a long axis of said first optic fiber.

9. Guide wire guiding apparatus in accordance with claim 2 wherein said second optic fiber second end is polished flat.

10. Guide wire guiding apparatus in accordance with claim 2 wherein said second optic fiber second end is polished at an angle of about 8 degrees relative to a cross-sectional plane orthonormal to a long axis of said first optic fiber.

11. Guide wire guiding apparatus in accordance with claim 1 further comprising a visual graphic display coupled to said interferometric system, said visual graphic display configured to display the interferometric information and the Doppler shift information.

12. Apparatus for detecting neovascular flow through an obstruction in a blood vessel, said apparatus comprising:

a guide wire having a first proximal end and second distal end;

at least one interferometric guidance system comprising a fiber coupled to and extending beyond said guide wire distal end;

an interferometric apparatus coupled to said guide wire proximal end and configured to receive data relating to neovascular flow from said fiber;

a broad band filter coupled to an output of said interferometric apparatus, said interferometric apparatus generating interferometric peaks of varying frequencies; and

a frequency-to-voltage converter coupled in series to said broad band filter.

13. Apparatus in accordance with claim 12 further comprising an FM detector coupled to an output of said broad band filter and providing an input to said frequency-to-voltage converter.

14. A method to determine neovascular flow through tissue in a vessel, said method comprising:

using an apparatus configured to guide a guide wire through body tissue which comprises a guide wire having a first proximal end and second distal end, and at least one interferometric guidance system comprising at least one stationary optical fiber coupled to and extending beyond the guide wire distal end;

examining the vessel with the interferometric system; and

performing a Doppler shift analysis on frequencies of interference peaks generated by the interferometric system examining the vessel to determine the velocity of blood.

15. A method in accordance with claim 14 wherein performing the Doppler shift analysis includes the steps of:

applying a known amplitude-modulated voltage signal to a first PZT and a second PZT to produce a first known component of a Doppler frequency shift in the frequencies of interference peaks;

measuring an actual Doppler frequency shift in the interference peaks;

subtracting the first known component of the Doppler frequency shift from the actual Doppler frequency shift to determine a second component of the actual Doppler frequency shift, wherein the second component reveals the presence of neovascular channels in the vessel.

16. A method in accordance with claim 15 wherein subtracting the first known component from the actual Doppler frequency shift to determine a second known component comprises the step of determining whether the second component has an increase in magnitude.

17. A method in accordance with claim 14 wherein performing a Doppler shift analysis comprises comparing an actual shift to a predicted shift of the path length change velocity whereby the velocity path component is constant and the observed variance is from a velocity change of the sample component.

18. A method in accordance with claim 14 wherein the neovascular flow is determined by linear changes in the path length of a signal generated by the interferometric system.