Pre-filled drug-delivery device and method of manufacture and assembly of same

• US 6,843,782 B2
• Filed: 04/18/2001
• Issued: 01/18/2005
• Est. Priority Date: 06/16/1997
• Status: Expired due to Term

• Current Assignee: Elan Pharma International Limited (Perrigo Company PLC)
• Original Assignee: Elan Pharma International Limited (Perrigo Company PLC)
• Inventors: Tsals, Izrail, Lavi, Gilad, Gross, Joseph
• Primary Examiner(s): Hayes, Michael J.
• Application Number:
  US09/836,964
• Publication Number:
  US 20010025168A1
• Time in Patent Office: 1,371 Days
• Field of Search: 604/93, 604/110, 604/111, 604/192, 604/198, 604/233, 604/239, 604/263, 604/264, 604/131, 604/272, 604/134, 604/135, 604/140, 604/141, 604/143, 604/145, 604/506
• US Class Current: 604/141
• CPC Class Codes: A61M 2005/14204 with gas-producing electrochemical cell
• CPC Class Codes: A61M 2005/14252 with needle insertion means
• CPC Class Codes: A61M 2005/1426 with means for preventing access to the needle after use
• CPC Class Codes: A61M 2005/1581 Right-angle needle-type devices
• CPC Class Codes: A61M 2005/3128 Incorporating one-way valves, e.g. pressure-relief or non-return valves
• CPC Class Codes: A61M 2005/3132 having flow passages for injection agents at the distal end of the barrel to bypass a sealing stopper after its displacement to this end due to internal pressure increase
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/14526 the piston being actuated by fluid pressure
• CPC Class Codes: A61M 5/2046 Media being expelled from injector by gas generation, e.g. explosive charge
• CPC Class Codes: A61M 5/2066 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/31563 interacting with a displaceable stop member
• CPC Class Codes: A61M 5/31591 Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means
• CPC Class Codes: A61M 5/422 Desensitising skin
• CPC Class Codes: A61M 5/50 having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile retractable needles or needle protectors with means for preventing re-use A61M5/321

Abstract

A drug delivery device having a base member defining a skin-contacting surface, a syringe serving as a reservoir for the drug, and means for expelling drug from the syringe. The syringe is connected to the base member such that the longitudinal axis of the syringe is substantially parallel to the skin surface. A delivery needle is in communication with the syringe. The needle has an angled bend which directs the tip of the needle substantially perpendicular to the skin-contacting surface. In use, the tip of the needle is adapted to penetrate the skin of the subject.

Claims

1. A method of delivering drug to a subject comprising:

providing a drug delivery device having a base member defining a skin-contacting surface, a syringe serving as a reservoir for a drug, a delivery needle coupled to said syringe, and means for expelling the drug out of the interior of said syringe and through said needle, said needle having a tip, said syringe having a longitudinal axis and being movably coupled to said base member from a first position to a second position, said longitudinal axis of said syringe when in said first position being at an angle to said skin contacting surface, said longitudinal axis of said syringe when in said second position being substantially parallel to said skin contacting surface;

applying said device to the skin of the subject whereupon said longitudinal axis of said syringe is in said first position, said needle having first portion extending along said longitudinal axis and an angled bend which directs said tip of said needle at an angle to said longitudinal axis; and

activating said device to cause said longitudinal axis of said syringe to be in said second position and to cause said tip of the needle to penetrate the skin of the subject independently of said means for expelling the drug.

2. The method of claim 1, wherein said tip of said needle is substantially perpendicular to said longitudinal axis of said syringe.

3. The method of claim 1, wherein said means for expelling the drug comprises a gas generator.

4. The method of claim 1, wherein said syringe is prefilled.

5. The method of claim 1, wherein said device comprises a housing to which said base member is coupled and said device is activated by moving said housing towards said base member.

6. The method of claim 5, wherein the movement of said housing towards said base member simultaneously causes said tip of said needle to penetrate the skin.

7. The method of claim 1, wherein said device further comprises a housing and wherein said method further comprises causing said device to lock into a retracted position after use, whereby said tip of said needle is recessed within said housing.