Method, system, and apparatus for measurement and recording of blood chemistry and other physiological measurements

• US 6,844,149 B2
• Filed: 06/29/2001
• Issued: 01/18/2005
• Est. Priority Date: 06/29/2001
• Status: Expired due to Fees

• Current Assignee: Pendragon Networks LLC (Pendrell Corporation)
• Original Assignee: International Business Machines Corporation
• Inventors: Goldman, Richard Mark
• Primary Examiner(s): Marschel, Ardin H.
• Application Number:
  US09/895,588
• Publication Number:
  US 20030003522A1
• Time in Patent Office: 1,299 Days
• Field of Search: 435/4, 435/11, 435/14, 435/18, 422/50, 422/68.1, 702/19, 702/27, 703/11
• US Class Current: 435/4
• CPC Class Codes: G01N 33/558 using diffusion or migration of antigen or antibody immunochromatographic test strips G01N33/54387
• CPC Class Codes: G01N 33/66 involving blood sugars, e.g. galactose
• CPC Class Codes: G01N 33/723 Glycosylated haemoglobin
• CPC Class Codes: G01N 33/725 using peroxidative activity
• CPC Class Codes: G01N 33/86 involving blood coagulating time or factors, or their receptors
• CPC Class Codes: G01N 33/92 involving lipids, e.g. cholesterol , lipoproteins, or their receptors steroid hormones G01N33/743

Abstract

A multi-component test strip for analyzing a plurality of blood components in a single blood sample. The test strip comprises a porous medium having a sample receiving region, and two or more sample analysis regions. The sample receiving region is fluidically in series with the two or more sample analysis regions, and the two or more sample analysis regions are fluidically in parallel with each other. The two or more sample analysis regions contain indicating reagents specific to two or more specific blood components. Also disclosed is a system using the test strip for blood characterization, and a method of blood characterization and analysis.

Claims

1. A method of measuring, digitizing, and storing blood component data comprising the steps of:

(a) depositing a blood sample on a test strip having two or more distinct regions for detecting and indicating the presence and concentration of blood fractions including (i) blood glucose and (ii) at least one other blood component chosen from the group consisting of glycosylated hemoglobin, cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, hemoglobin, and clotting factors;

said test strip having at least one portion for measuring blood glucose, said portion comprising a fibrous, polyamide matrix containing immobilized glucose oxidase and immobilized glucose peroxidase;

(b) measuring, digitizing, and storing indications of blood fraction concentration in an associated meter configured to read blood fraction presence and concentration indications, digitize the indications, store the digitized indications, and transmit the digitized indications; and

(c) transmitting the stored indications of blood fraction indication to a server.

2. A method of analyzing, measuring, recording, and uploading biological functions comprising the steps of:

(a) analyzing a blood sample from a subject for concentrations of components thereof including (i) blood glucose and (ii) at least one other blood component chosen from the group consisting of glycosylated hemoglobin, cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, hemoglobin, and clotting factors;

said test strip having at least one portion for measuring blood glucose, said portion comprising a fibrous, polyamide matrix containing immobilized glucose oxidase and immobilized glucose peroxidase;

(b). recording the concentrations in a memory;

(c) measuring and recording cardiovascular measures of the subject chosen from the group consisting of blood pressure, respiration rate, and electrocardiogram in the memory; and

(d) uploading the recorded blood component concentrations and cardiovascular measures to a remote server.

3. The method of claim 2 comprising determining the blood component concentrations by the method of:

(a) depositing a blood sample on a test strip having two or more distinct regions for detecting and indicating the presence and concentration of blood fractions; and

(b) measuring, digitizing, and storing indications of blood fraction concentration in an associated meter configured to read blood fraction presence and concentration indications, digitize the indications, store the digitized indications, and transmit the digitized indications.

4. The method of claim 2 wherein the cardiovascular measure is an electrocardiogram, and the electrocardiogram is compressed before transmission to the server.