Systems and methods for modulation of circulatory perfusion by electrical and/or drug stimulation

• US 6,845,267 B2
• Filed: 08/30/2001
• Issued: 01/18/2005
• Est. Priority Date: 09/28/2000
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Advanced Bionics Corporation (Sonova Holding AG)
• Inventors: Whitehurst, Todd K., Harrison, William Vanbrooks
• Primary Examiner(s): Jastrzab, Jeffrey P.
• Assistant Examiner(s): Oropeza, Frances P.
• Application Number:
  US09/943,550
• Publication Number:
  US 20040082978A1
• Time in Patent Office: 1,237 Days
• Field of Search: 604/891.1, 128/897, 128/899, 607 1- 3, 607/33, 607/48, 607/52, 607/61, 607/62, 607/116
• US Class Current: 607/3
• CPC Class Codes: A61N 1/32 alternating or intermittent currents applying electric fields by inductive or capacitive coupling A61N1/40; microwave apparatus A61N5/02

Abstract

One or more implantable system control units (SCU) apply one or more stimulating drugs and/or electrical pulses to one or more predetermined areas affecting circulatory perfusion. The SCU preferably includes a programmable memory for storing data and/or control parameters, and preferably uses a power source/storage device, such as a rechargeable battery. If necessary, periodic recharging of such a power source/storage device is accomplished, for example, by inductive coupling with an external appliance. The SCU provides a means of stimulating a nerve(s) or other tissue with electrical and/or infusion pulses when desired, without the need for external appliances during the stimulation session. When necessary, external appliances are used for the transmission of data to and/or from the SCU(s) and/or for the transmission of power. In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust electrical and/or drug stimulation parameters.

Claims

1. A method for modulating circulatory perfusion in coordination with delivery of medication, comprising:

implanting at least one system control unit in the body of the patent,

wherein the at least one unit controls the delivery of at least one electrical stimulus to at least a first predetermined area affecting circulatory perfusion;

applying the at least one stimulus to the at least first predetermined area in order to modulate circulatory perfusion in at least a second area of the patient being treated wherein the at least second area includes tissue targeted to receive medication;

delivering medication to the at least second area of the patient being treated; and

modifying the stimulus applied to the at least first predetermined area to cause hyperfusion in the at least second area,

wherein perfusion of the medication is restricted due to the hyperfusion in the second area of the patient being treated.

2. The method of claim 1 wherein the first area and the second area are the same area.

3. The method of claim 1 wherein the electrical stimulus is delivered to at least one of a smooth muscle and a skeletal muscle at greater than about 50 to 100 Hz to relax the at least one smooth muscle and skeletal muscle.

4. The method of claim 1 wherein the electrical stimulus is delivered to at least one of a smooth muscle and a skeletal muscle at less than about 50 to 100 Hz to excite the at least one smooth muscle and skeletal muscle.

5. The method of claim 1 wherein the electrical stimulus is delivered to at least one smooth muscle at less than about 1-10 mA to relax the at least one smooth muscle.

6. The method of claim 1 wherein the medication is delivered locally.

7. The method of claim 1 further comprising implanting more than one system control unit.

8. The method of claim 1 further comprising sensing a condition and using the sensed condition to automatically determine the stimulus to apply.

9. A method for modulating circulatory perfusion in coordination with delivery of medication, comprising:

implanting at least one system control unit in the body of the patient,

wherein the at least one unit controls the delivery of electrical stimulation to at least a first predetermined area affecting circulatory perfusion;

applying the electrical stimulation to the at least first predetermined area in order to modulate circulatory perfusion in at least a second area of the patient being treated wherein the at least second area includes tissue targeted to receive medication;

delivering medication to the at least third area of the patient being treated; and

modifying the stimulus applied to the at least first predetermined area to cause hyperperfusion in the at least second area,

wherein the medication is focused into the second area of the patient due to the hyperperfusion in the second area of the patient being treated.

10. The method of claim 9 wherein the medication is delivered to the bloodstream from at least one of an artery and a vein.

11. The method of claim 9 wherein the medication is delivered systemically.

12. The method of claim 9 further comprising implanting more than one system control unit.

13. The method of claim 9 wherein the first area and the second area are the same area.

14. The method of claim 9 wherein the electrical stimulation excites parasympathetic neural activity.

15. The method of claim 9 wherein the electrical stimulation inhibits sympathetic neural activity.

16. The method of claim 9 wherein the electrical stimulation is delivered at less than about 1-10 mA.

17. The method of claim 9 further comprising sensing a condition and using the sensed condition to automatically determine the stimulus to apply.

18. The method of claim 9 wherein the electrical stimulation is delivered to at least one of a smooth muscle and a skeletal muscle at greater than about 50 to 100 Hz to relax the at least one smooth muscle and skeletal muscle.

19. The method of claim 9 wherein the electrical stimulation is delivered to at least one of a smooth muscle and a skeletal muscle at less than about 50 to 100 Hz to excite the at least one smooth muscle and skeletal muscle.