Methods and apparatus for loading radioactive seeds into brachytherapy needles

• US 6,846,283 B2
• Filed: 04/25/2002
• Issued: 01/25/2005
• Est. Priority Date: 03/09/2000
• Status: Expired due to Fees

• Current Assignee: Neose Technologies, Inc.
• Original Assignee: Neose Technologies, Inc.
• Inventors: Green, Thomas C., Boucher, Ryan P., Belman, Yuri
• Primary Examiner(s): Lacyk, John P.
• Application Number:
  US10/134,098
• Publication Number:
  US 20040162458A1
• Time in Patent Office: 1,006 Days
• Field of Search: 600 1- 8
• US Class Current: 600/7
• CPC Class Codes: A61M 2210/166 Prostate
• CPC Class Codes: A61M 37/0069 Devices for implanting pellets, e.g. markers or solid medicaments for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027
• CPC Class Codes: A61M 5/329 characterised by features of the needle shaft
• CPC Class Codes: A61N 2005/1009 Apparatus for loading seeds into magazines or needles
• CPC Class Codes: A61N 2005/101 Magazines or cartridges for seeds
• CPC Class Codes: A61N 2005/1011 Apparatus for permanent insertion of sources
• CPC Class Codes: A61N 5/1007 Arrangements or means for the introduction of sources into the body
• CPC Class Codes: A61N 5/1027 Interstitial radiation therapy

Abstract

Methods and apparatus are provided for loading therapeutic materials into brachytherapy needles. The apparatus comprises an apparatus with chambers, and radioactive seed and spacer cartridges received therein. The apparatus may be used in conjunction with a standard brachytherapy needle coupled to the distal end of the apparatus. The plunger dislodges seeds and spacers from the cartridge chambers to load the needle with a predetermined packing arrangement.

Claims

1. Apparatus for loading therapeutic materials into a brachytherapy needle comprising:

a collection chamber having a distal end configured to communicate with a brachytherapy needle;

a first cartridge comprising a plurality of seeds, the first cartridge disposed in communication with the collection chamber;

a second cartridge comprising a plurality of spacers, the second cartridge disposed in communication with the collection chamber; and

first and second loading chambers, each one of the first and second loading chambers having an end in communication with the collection chamber and a second end configured to receive seeds and spacers from the first and second loading cartridges, respectively.

2. The apparatus of claim 1 further comprising a first loading stylet disposed for reciprocation through the first loading chamber.

3. The apparatus of claim 2 further comprising a second loading stylet disposed for reciprocation through the second loading chamber.

4. The apparatus of claim 3 further comprising means for controlling reciprocation of the first and second stylets.

5. The apparatus of claim 1 wherein the collection chamber is adapted to move perpendicularly to selectively align with the first and second loading chambers.

6. The apparatus of claim 5 further comprising means for ensuring correct alignment of the collection chamber with the first and second loading chambers.

7. The apparatus of claim 1 wherein the first and second loading chambers are adapted to move perpendicularly to selectively align with the collection chamber.

8. The apparatus of claim 7 further comprising means for ensuring correct alignment of the first and second loading chambers with the collection chamber.

9. The apparatus of claim 1 wherein the first loading chamber and the second loading chamber are deposited in tandem and proximal to the collection chamber.

10. The apparatus of claim 9 further comprising a loading stylet proximal and disposed for reciprocation through first and the second loading chambers.

11. The apparatus of claim 10 wherein the first and second loading chambers are further configured to be independently moved out of alignment with the loading stylet and the collection chamber.

12. The apparatus of claim 11 further comprising means for ensuring correct alignment of the first and second loading chambers to the loading stylet and the collection chamber.

13. The apparatus of claim 1 further comprising a third loading chamber and a third cartridge containing a plurality of radioactive seeds or a plurality of spacers, the third cartridge disposed in communication with the third loading chamber, and interposed between the loading stylet and collection chamber.

14. The apparatus of claim 13 wherein the loading stylet and collection chamber are configured to align with any of the first, second or third loading chambers.

15. The apparatus of claim 14 further comprising means for ensuring correct alignment of the stylet and the collection chamber with the first, second or third loading chambers.

16. The apparatus of claim 1 wherein the seeds or spacers contained within the first and second cartridges are urged towards the first and second loading chambers by spring force.

17. The apparatus of claim 1 wherein the seeds or spacers contained within the first and second cartridges are urged towards the first and second loading chambers by gravity.

18. The apparatus of claim 1 wherein the seeds or spacers contained within the first and second cartridges are urged towards the first and second loading chambers by weighted body.

19. The apparatus of claim 1 wherein the seeds or spacers contained within the first and second cartridges are urged towards the first and second loading chambers by directional ratchet.

20. The apparatus of claim 1 wherein the seeds or spacers contained within the first and second cartridges are delivered to the first and second loading chambers by rotating feed drums.

21. Apparatus for loading therapeutic materials into a brachytherapy needle comprising:

a collection chamber having a distal end configured to communicate with a brachytherapy needle;

a first cartridge comprising a plurality of seeds, the first cartridge disposed in communication with the collection chamber; and

a second cartridge comprising a plurality of spacers, the second cartridge disposed in communication with the collection chamber,

wherein the first and second cartridges are cylindrical in shape, with the plurality of seeds or spacers arranged circumferentially therein.

22. Apparatus for loading therapeutic materials into a brachytherapy needle comprising:

a collection chamber having a distal end configured to communicate with a brachytherapy needle;

a first cartridge comprising a plurality of seeds, the first cartridge disposed in communication with the collection chamber; and

a second cartridge comprising a plurality of spacers, the second cartridge disposed in communication with the collection chamber,

wherein the first and second cartridges further comprise means for viewing quantity of seeds or spacers contained therein.

23. Apparatus for loading therapeutic materials into a brachytherapy needle comprising:

a collection chamber having a distal end configured to communicate with a brachytherapy needle;

a first cartridge comprising a plurality of seeds, the first cartridge disposed in communication with the collection chamber; and

a second cartridge comprising a plurality of spacers, the second cartridge disposed in communication with the collection chamber,

wherein the first and second cartridges further comprise indicia corresponding to quantity of seeds or spacers contained therein.

24. Apparatus for loading therapeutic materials into a brachytherapy needle comprising:

a collection chamber having a distal end configured to communicate with a brachytherapy needle;

a first cartridge comprising a plurality of seeds, the first cartridge disposed in communication with the collection chamber;

a second cartridge comprising a plurality of spacers, the second cartridge disposed in communication with the collection chamber; and

means for wrapping the seeds and spacers of the collection chamber in a bio-compatible member.

25. The apparatus of claim 24 wherein the bio-compatible member is bio-absorbable.

26. The apparatus of claim 24 wherein the bio-compatible member comprises means for retaining seeds or spacers wrapped therein.

27. Apparatus for loading therapeutic materials into a brachytherapy needle comprising:

a collection chamber having a distal end configured to communicate with a brachytherapy needle;

a first cartridge comprising a plurality of seeds, the first cartridge disposed in communication with the collection chamber; and

a second cartridge comprising a plurality of spacers, the second cartridge disposed in communication with the collection chamber,

wherein the collection chamber further comprises means for viewing, removing, or manipulating the contents of the collection chamber.

28. Apparatus for loading therapeutic materials into a brachytherapy needle comprising:

a collection chamber having a distal end configured to communicate with a brachytherapy needle;

a first cartridge comprising a plurality of seeds, the first cartridge disposed in communication with the collection chamber; and

a second cartridge comprising a plurality of spacers, the second cartridge disposed in communication with the collection chamber,

wherein the collection chamber further comprises means for providing radiation protection from the radioactive seeds contained in the collection chamber.

29. Apparatus for loading therapeutic materials into a brachytherapy needle comprising:

a collection chamber having a distal end configured to communicate with a brachytherapy needle;

a first cartridge comprising a plurality of seeds, the first cartridge disposed in communication with the collection chamber; and

a second cartridge comprising a plurality of spacers, the second cartridge disposed in communication with the collection chamber,

wherein the collection chamber further comprises means for measuring radiation from the radioactive seeds contained therein.

30. A method of preparing therapeutic materials for loading into a brachytherapy needle comprising:

providing apparatus comprising first and second loading chambers, a first cartridge comprising a plurality of radioactive seeds, the first cartridge disposed in communication with the first loading chamber, a second cartridge comprising a plurality of spacers, the second cartridge disposed in communication with the second loading chamber, a collection chamber having a proximal end in communication with the first and second loading chambers and a distal end adapted to communicate with a brachytherapy needle, the collection chamber configured to receive seeds and spacers from the first and second loading chambers, a plunger configured for reciprocation through the collection chamber, and a brachytherapy needle;

providing a reciprocating first loading stylet proximal to the first loading chamber and a reciprocating second loading stylet proximal to the second loading chamber;

coupling the distal end of the collection chamber within a lumen of a brachytherapy needle; and

depositing a seed or a spacer into the first and second loading chambers from the first and second cartridges, respectively.

31. The method of claim 30 further comprising:

providing a first loading stylet proximal to the first loading chamber and second loading stylet proximal to the second loading chamber;

distally advancing the first loading stylet to push a radioactive seed in the first loading chamber into the distal end of the collection chamber; and

proximally retracting the first loading stylet, allowing another radioactive seed to be deposited in the first loading chamber from the first cartridge.

32. The method of claim 31 further comprising:

distally advancing the second loading stylet to push a spacer in the second loading chamber into the distal end of the collection chamber; and

proximally retracting the second loading stylet, allowing another spacer to be deposited in the second loading chamber from the second cartridge.

33. The method of claim 32 further comprising loading the collection chamber with seeds and spacers in a predetermined packing arrangement.

34. The method of claim 33 further comprising distally advancing the plunger to push the seeds and spacers within the collection chamber into the brachytherapy needle.