Gentle-acting skin disinfectants

• US 6,846,846 B2
• Filed: 10/23/2001
• Issued: 01/25/2005
• Est. Priority Date: 10/23/2001
• Status: Active Grant

• Current Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Original Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Inventors: Modak, Shanta, Sampath, Lester, Gaonkar, Trupti A.
• Primary Examiner(s): Criares, Theodore J.
• Application Number:
  US10/047,631
• Publication Number:
  US 20030152644A1
• Time in Patent Office: 1,190 Days
• Field of Search: 514/494, 514/635, 514/643, 514/722, 514/642, 514/481, 424/65
• US Class Current: 514/722
• CPC Class Codes: A61K 2800/75 Anti-irritant
• CPC Class Codes: A61K 31/79 Polymers of vinyl pyrrolidone
• CPC Class Codes: A61K 8/042 Gels
• CPC Class Codes: A61K 8/347 Phenols
• CPC Class Codes: A61K 8/416 Quaternary ammonium compounds A61K8/35 takes precedence
• CPC Class Codes: A61K 8/43 Guanidines
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations

Abstract

Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin.

Claims

1. An antimicrobial composition comprising synergistic effective amounts of octoxyglycerin, a quaternary ammonium compound, and an antimicrobial agent selected from the group consisting of biguanide compound, triclosan, phenoxyethanol, an iodine compound and parachlorometaxylenol.

2. The composition of claim 1 wherein the concentration of octoxyglycerin is between 1 and 5 percent (volume/volume).

3. The composition of claim 1 wherein the concentration of quaternary ammonium compound is between 0.01 and 0.3 percent.

4. The composition of claim 2 wherein the concentration of quaternary ammonium compound is between 0.01 and 0.3 percent.

5. The composition of claim 1 or 2 wherein the antimicrobial agent is a biguanide compound at a concentration of between 0.5 and 4 percent.

6. The composition of claim 5 wherein the biguanide compound is a chlorhexidine compound.

7. The composition of claim 3 or 4 wherein the antimicrobial agent is a biguanide compound at a concentration of between 0.5 and 4 percent.

8. The composition of claim 7 wherein the biguanide compound is a chlorhexidine compound.

9. The composition of claim 1 wherein the antimicrobial agent is triclosan at a concentration of between 0.1 and 2 percent.

10. The composition of claim 2 wherein the antimicrobial agent is triclosan at a concentration of between 0.1 and 2 percent.

11. The composition of claim 3 wherein the antimicrobial agent is triclosan at a concentration of between 0.1 and 2 percent.

12. The composition of claim 4 wherein the antimicrobial agent is triclosan at a concentration of between 0.3 and 2 percent.

13. The composition of claim 1 wherein the antimicrobial agent is phenoxyethanol at a concentration of between 0.3 and 2 percent.

14. The composition of claim 2 wherein the antimicrobial agent is phenoxyethanol at a concentration of between 0.3 and 2 percent.

15. The composition of claim 3 wherein the antimicrobial agent is phenoxyethanol at a concentration of between 0.3 and 2 percent.

16. The composition of claim 4 wherein the antimicrobial agent is phenoxyethanol at a concentration of between 0.3 and 2 percent.

17. The composition of claim 1 wherein the antimicrobial agent is parachlorometaxylenol at a concentration of between 0.3 and 2 percent.

18. The composition of claim 2 wherein the antimicrobial agent is parachlorometaxylenol at a concentration of between 0.3 and 2 percent.

19. The composition of claim 3 wherein the antimicrobial agent is parachlorometaxylenol at a concentration of between 0.3 and 2 percent.

20. The composition of claim 4 wherein the antimicrobial agent is parachlorometaxylenol at a concentration of between 0.3 and 2 percent.

21. The antimicrobial composition of claim 1 which further comprises between 20 and 85 percent (volume/volume) of ethanol.

22. The antimicrobial composition of claim 1 which further comprises between 20 and 85 percent (volume/volume) of isopropanol.

23. The antimicrobial composition of claim 1, 2 or 3 which further comprises between 3 and 10 percent (volume/volume) hexanol.

24. The antimicrobial composition of claim 1 which further comprises between 0.2 and 7 percent of a zinc compound selected from the group consisting of zinc gluconate, zinc oxide, zinc acetate, zinc stearate and zinc salicylate.

25. An antimicrobial composition comprising synergistic effective amounts of between 1 and 5 percent (volume/volume) octoxyglycerin, between 0.05 and 0.2 percent of benzalkonium chloride, and between 0.5 and 4 percent of chlorhexidine digluconate.

26. The antimicrobial composition of claim 25 which further comprises between 20 and 85 percent (volume/volume) of ethanol.

27. The antimicrobial composition of claim 25 which further comprises between 20 and 85 percent (volume/volume) of isopropanol.

28. The antimicrobial composition of claim 25 which further comprises between 3 and 10 percent (volume/volume) hexanol.

29. The antimicrobial composition of claim 25 which further comprises between 0.2 and 7 percent of a zinc compound selected from the group consisting of zinc gluconate, zinc oxide, zinc stearate and zinc salicylate.

30. An antimicrobial composition comprising synergistic effective amounts of between 1 and 5 percent (volume/volume) octoxyglycerin, between 0.5 and 4 percent of a chlorhexidine compound, and between 1 and 2 percent of miconazole.

31. An antimicrobial composition comprising synergistic effective amounts of between 1 and 5 percent (volume/volume) octoxyglycerin, between 0.5 and 4 percent of a chlorhexidine compound, and between 0.3 and 1 percent polymixin.

32. An antimicrobial composition comprising synergistic effective amounts of between 1 and 5 percent (volume/volume) octoxyglycerin, between 0.5 and 4 percent of a chlorhexidine compound, and between 0.1 and 0.5 percent neomycin.

33. The composition of claim 32, further comprising between 0.3 and 1 percent polymixin.

34. An antimicrobial composition comprising synergistic effective amounts of between 1 and 5 percent (volume/volume) octoxyglycerin, between 0.5 and 4 percent of a chlorhexidine compound, and between 1 and 2 percent silver sulfadiazine.

35. An antimicrobial composition comprising synergistic effective amounts of between 1 and 5 percent (volume/volume) octoxyglycerin, between 0.5 and 4 percent of chlorhexidine digluconate, and between 1 and 2 percent of miconazole.

36. An antimicrobial composition comprising synergistic effective amounts of between 1 and 5 percent (volume/volume) octoxyglycerin, between 0.5 and 4 percent of chlorhexidine digluconate, and between 0.3 and 1 percent polymixin.

37. An antimicrobial composition comprising synergistic effective amounts of between 1 and 5 percent (volume/volume) octoxyglycerin, between 0.5 and 4 percent of chlorhexidine digluconate, and between 0.1 and 0.5 percent neomycin.

38. The composition of claim 37, further comprising between 0.3 and 1 percent polymixin.

39. An antimicrobial composition comprising synergistic effective amounts of between 1 and 5 percent (volume/volume) octoxyglycerin, between 0.5 and 4 percent of chlorhexidine digluconate, and between 1 and 2 percent silver sulfadiazine.

40. An antimicrobial composition comprising synergistic effective amounts of between 1 and 5 percent (volume/volume) octoxyglycerin, between 0.05 and 2 percent of chlorhexidine digluconate, between 0.3 and 2 percent of phenoxyethanol, between 0.01 and 0.3 percent of a quaternary ammonium compound, and between 20 and 85 percent of an alcohol elected from the group consisting of ethanol and isopropyl alcohol.