Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof

• US 6,846,919 B2
• Filed: 06/19/2002
• Issued: 01/25/2005
• Est. Priority Date: 04/14/1998
• Status: Expired due to Fees

• Current Assignee: Arena Pharmaceuticals Incorporated (Pfizer Inc.)
• Original Assignee: Arena Pharmaceuticals Incorporated (Pfizer Inc.)
• Inventors: Russo, Joseph F, Liaw, Chen W, Thomsen, William J, Behan, Dominic P, Chalmers, Derek T
• Primary Examiner(s): Brumback, Brenda
• Assistant Examiner(s): BASI, NIRMAL SINGH
• Application Number:
  US10/176,255
• Publication Number:
  US 20030153004A1
• Time in Patent Office: 951 Days
• Field of Search: 435/7.1, 435/69.1, 435/172.3, 435/325, 435/320.1, 435/235.1, 536/23.1, 536/23.5, 530/300, 530/350
• US Class Current: 536/23.1
• CPC Class Codes: C07D 231/12 with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• CPC Class Codes: C07D 231/16 Halogen atoms or nitro radicals
• CPC Class Codes: C07D 409/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07K 14/70571 for neuromediators, e.g. serotonin receptor, dopamine receptor
• CPC Class Codes: C07K 14/723 G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
• CPC Class Codes: G01N 2333/70571 for neuromediators, e.g. serotonin receptor, dopamine receptor
• CPC Class Codes: G01N 2333/726 G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
• CPC Class Codes: G01N 33/566 using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds

Abstract

Disclosed herein are non-endogenous, constitutively activated forms of the human 5-HT_2A and human 5-HT_2C receptors and uses of such receptors to screen candidate compounds. Further disclosed herein are candidate compounds identified by the screening method which act at the 5HT_2A receptors. Yet further disclosed is a new class of compounds which act at the 5HT_2A receptors.

Claims

1. An isolated nucleic acid comprising SEQ ID NO:

30.