Use of borate-polyol complexes in ophthalmic compositions
DCFirst Claim
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1. An aqueous ophthalmic solution comprising:
- 0.5 to 6.0 wt. % of a water soluble borate-polyol complex to enhance the antimicrobial activity of the solution, and water;
wherein the borate-polyol complex comprises a borate compound selected from the group consisting of boric acid and pharmaceutically acceptable salts thereof and propylene glycol, and the molar ratio of borate to polyol is 1;
0.1 to 1;
10.
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Abstract
Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the borate-polyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.
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18 Claims
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1. An aqueous ophthalmic solution comprising:
- 0.5 to 6.0 wt. % of a water soluble borate-polyol complex to enhance the antimicrobial activity of the solution, and water;
wherein the borate-polyol complex comprises a borate compound selected from the group consisting of boric acid and pharmaceutically acceptable salts thereof and propylene glycol, and the molar ratio of borate to polyol is 1;
0.1 to 1;
10. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- 0.5 to 6.0 wt. % of a water soluble borate-polyol complex to enhance the antimicrobial activity of the solution, and water;
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10. An aqueous ophthalmic solution comprising:
- 0.5 to 6.0 wt. % of a water soluble borate-polyol complex to enhance the antimicrobial activity of the solution, and water;
wherein the borate-polyol complex comprises a borate compound selected from the group consisting of boric acid and pharmaceutically salts thereof and sorbitol, and the molar ratio of borate to polyol is 1;
0.1 to 1;
10. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
- 0.5 to 6.0 wt. % of a water soluble borate-polyol complex to enhance the antimicrobial activity of the solution, and water;
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