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Apparatus and method for drug screening

  • US 6,849,403 B1
  • Filed: 11/28/2000
  • Issued: 02/01/2005
  • Est. Priority Date: 09/08/1999
  • Status: Expired due to Fees
First Claim
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1. A method for screening drug activity, the method comprising the steps of:

  • (a) determining a baseline level of high integrity nucleic acid associated with a nucleic acid locus in a first sample obtained from a patient having a disease or at least one indicium of a disease, wherein the high integrity nucleic acid is derived from a genome of the patient and the disease comprises at least one of cancer, pre-cancer, a disease associated with apoptosis, and a disease associated with programmed cell death;

    (b) treating the patient with a drug candidate; and

    (c) determining whether the high integrity nucleic acid associated with the nucleic acid locus in a second sample obtained from the patient is reduced.

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