Cellular kinases involved in Cytomegalovirus infection and their inhibition
First Claim
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1. Method for identifying compounds useful for treating and/or preventing Cytomegalovirus infection comprising:
- a) contacting a test compound with cellular kinase RIP (SEQ ID NO;
16); and
b) detecting a decrease in activity of said cellular kinase, wherein said decrease in activity of said cellular kinase indicates said test compound would be useful for treating and/or preventing CMV infection.
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Abstract
The role of certain cellular kinases active during Human Cytomegalovirus infection is disclosed. These cellular kinases are useful to detect HCMV infection, and can be used to screen for cellular kinase inhibitors. Cellular kinases inhibitors, which effectively downregulate these key cellular components, serve as effective therapeutics against HCMV infection.
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1 Claim
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1. Method for identifying compounds useful for treating and/or preventing Cytomegalovirus infection comprising:
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a) contacting a test compound with cellular kinase RIP (SEQ ID NO;
16); and
b) detecting a decrease in activity of said cellular kinase, wherein said decrease in activity of said cellular kinase indicates said test compound would be useful for treating and/or preventing CMV infection.
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Specification