Combinatorial strategies for polymer synthesis
First Claim
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1. A method of forming an array of polymers on a support having one or more localized areas comprising(a) depositing a resist onto a surface of the support;
- (b) selectively removing a portion of the resist to expose one or more localized areas;
(c) dispensing a first monomer onto the surface of the support at the one or more localized areas wherein the one or more localized areas are smaller than 1 cm2;
(d) allowing the first monomer to attach directly or indirectly to the surface of the support at the one or more localized areas;
(e) repeating steps (a) and (b) and then dispensing an additional group of added monomers onto the surface of the support at the one or more localized areas in a manner to couple with a compound at the one or more localized areas until an array of at least 10 different polymers at different localized areas is formed.
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Abstract
A method for producing arrays by depositing a resist on a substrate, selectively removing a portion of the resist to expose localized areas, dispensing a monomer to occupy a localized area of less than 1 cm2 of the surface of the support, allowing the monomer to bind directly or indirectly to the support and repeating the steps to produce an array of at least 10 different polymers is formed.
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Citations
52 Claims
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1. A method of forming an array of polymers on a support having one or more localized areas comprising
(a) depositing a resist onto a surface of the support; -
(b) selectively removing a portion of the resist to expose one or more localized areas;
(c) dispensing a first monomer onto the surface of the support at the one or more localized areas wherein the one or more localized areas are smaller than 1 cm2;
(d) allowing the first monomer to attach directly or indirectly to the surface of the support at the one or more localized areas;
(e) repeating steps (a) and (b) and then dispensing an additional group of added monomers onto the surface of the support at the one or more localized areas in a manner to couple with a compound at the one or more localized areas until an array of at least 10 different polymers at different localized areas is formed. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49)
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50. A method of forming an array of compounds on a support having one or more localized areas comprising
(a) depositing a resist onto a surface of the support; -
(b) selectively removing a portion of the resist to expose one or more localized areas;
(c) dispensing a compound onto the surface of the support at the one or more localized areas wherein the one or more localized areas are smaller than 1 cm2;
(d) allowing the compound to attach directly or indirectly to the surface of the support at the one or more localized areas;
(e) repeating steps (a) through (d) until an array of at least 10 different polymers at different localized areas is formed. - View Dependent Claims (51, 52)
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Specification