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Oligonucleotide modulation of cell adhesion

  • US 6,849,612 B2
  • Filed: 10/18/2001
  • Issued: 02/01/2005
  • Est. Priority Date: 01/21/1993
  • Status: Expired due to Fees
First Claim
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1. A method for preserving a corneal explant ex vivo, comprising incubating a corneal explant in a solution comprising a corneal storage medium and an antisense oligonucleotide between 8 and 50 nucleotides in length that is targeted to intercellular adhesion molecule-1 (ICAM-1), and wherein said antisense oligonucleotide inhibits the expression of intercellular adhesion molecule-1 (ICAM-1), and wherein inhibition of ICAM-1 expression results in preserving a corneal, explant ex vivo.

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