Selective brain stimulation using conditioning pulses
First Claim
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1. A method of electrically stimulating neural tissue of the brain comprising the steps of:
- providing a source of electrical pulses;
providing a first electrode;
providing an electrical return path;
connecting the first electrode to the source of electrical pulses;
placing the first electrode in tissue of a patient'"'"'s brain;
applying a hyperpolarizing electrical pre-pulse to the tissue through the first electrode wherein the tissue is more susceptible to subsequent electric stimulation;
applying a subsequent depolarizing electrical pulse to the tissue through the first electrode wherein an action potential is generated in the tissue.
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Abstract
Methods of electrically stimulating neural tissue of the brain are disclosed. A first electrode is placed in close proximity with tissue of a patient'"'"'s brain (e.g., in the brain, or on or near the surface of the brain). A hyperpolariziag electrical pre-pulse is applied to the tissue through the first electrode wherein the tissue is more susceptible to subsequent electric stimulation. A subsequent depolarizing electrical pulse is applied to the tissue through the first electrode wherein an action potential is generated in the tissue.
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Citations
51 Claims
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1. A method of electrically stimulating neural tissue of the brain comprising the steps of:
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providing a source of electrical pulses;
providing a first electrode;
providing an electrical return path;
connecting the first electrode to the source of electrical pulses;
placing the first electrode in tissue of a patient'"'"'s brain;
applying a hyperpolarizing electrical pre-pulse to the tissue through the first electrode wherein the tissue is more susceptible to subsequent electric stimulation;
applying a subsequent depolarizing electrical pulse to the tissue through the first electrode wherein an action potential is generated in the tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of electrically stimulating neural tissue of the brain comprising the steps of:
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providing a source of electrical pulses;
providing a first electrode;
providing an electrical return path;
connecting the first electrode to the source of electrical pulses;
placing the first electrode in tissue of a patient'"'"'s brain;
applying a depolarizing electrical pre-pulse to the tissue through the first electrode wherein the tissue is less susceptible to subsequent electric stimulation;
applying a subsequent depolarizing electrical pulse to the tissue through the first electrode wherein an action potential is generated in the tissue. - View Dependent Claims (12)
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13. A method of electrically stimulating neural tissue of the brain comprising the steps of:
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providing a source of electrical pulses;
providing a first electrode;
providing an electrical return path;
connecting the first electrode to the source of electrical pulses;
placing the first electrode on the surface of a patient'"'"'s brain;
applying a hyperpolarizing electrical pre-pulse to the tissue through the first electrode wherein the tissue is more susceptible to subsequent electric stimulation;
applying a subsequent depolarizing electrical pulse to the tissue through the first electrode wherein an action potential is generated in the tissue. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21)
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22. A method of electrically stimulating neural tissue of the brain comprising the steps of:
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providing a source of electrical pulses;
providing a first electrode;
providing an electrical return path;
connecting the first electrode to the source of electrical pulses;
placing the first electrode on the surface of a patient'"'"'s brain;
applying a depolarizing electrical pre-pulse to the tissue through the first electrode wherein the tissue is less susceptible to subsequent electric stimulation;
applying a subsequent depolarizing electrical pulse to the tissue through the first electrode wherein an action potential is generated in the tissue. - View Dependent Claims (23)
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24. A method of electrically stimulating neural tissue of the brain comprising the steps of:
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providing a source of electrical pulses;
providing a first electrode, a second electrode spaced from the first electrode and a third electrode spaced from the first electrode opposite the second electrode so that the first electrode is generally between the second and third electrodes;
providing an electrical return path;
connecting the first, second and third electrodes to the source of electrical pulses;
placing the first, second and third electrodes within a patient'"'"'s body in a patient'"'"'s brain;
applying a hyperpolarizing electrical pre-pulse to the tissue through the first electrode wherein the tissue is more susceptible to subsequent electric stimulation;
applying a depolarizing electrical pre-pulse to the tissue through the second and third electrodes wherein the tissue near the second and third electrodes is less susceptible to subsequent electric stimulation;
applying a subsequent depolarizing electrical pulse to the tissue through the first electrode wherein an action potential is generated in the tissue near the first electrode. - View Dependent Claims (25, 26)
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27. A method of electrically stimulating neural tissue of the brain comprising the steps of:
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placing a first electrode In tissue of a patient'"'"'s brain;
applying a hyperpolarizing electrical pre-pulse to the tissue through the first electrode wherein the tissue is more susceptible to subsequent electric stimulation; and
applying a subsequent depolarizing electrical pulse to the tissue through the first electrode wherein an action potential is generated in the tissue. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34)
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35. A method of electrically stimulating neural tissue of the brain comprising the steps of:
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placing a first electrode in close proximity with tissue of a patient'"'"'s brain;
applying a hyperpolarizing electrical pre-pulse to the tissue through the first electrode wherein the tissue is more susceptible to subsequent electric stimulation;
applying a subsequent depolarizing electrical pulse to the tissue through the first electrode wherein an action potential is generated in the tissue. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51)
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Specification