Methods and devices for nebulizing fluids

• US 6,851,626 B2
• Filed: 01/07/2002
• Issued: 02/08/2005
• Est. Priority Date: 01/07/2002
• Status: Active Grant

• Current Assignee: Novartis Pharma AG (Novartis Ag)
• Original Assignee: Aerogen, Inc. (Nektar Therapeutics)
• Inventors: Domingo, Nicanor A., Albulet, Paul, Patel, Rajan, Klimowicz, Michael
• Primary Examiner(s): Nguyen, Dinh Q.
• Application Number:
  US10/043,075
• Publication Number:
  US 20030127538A1
• Time in Patent Office: 1,128 Days
• Field of Search: 239/338, 222/325, 222/327, 222/402.2, 128/200.21, 128/200.22, 128/200.23, 128/200.16, 128/200.18, 128/200.12, 128/200.24, 128/200.26, 128/205.13, 128/898
• US Class Current: 239/338
• CPC Class Codes: A61M 11/007 Syringe-type or piston-type sprayers or atomisers
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 15/0068 Indicating or counting the number of dispensed doses or of remaining doses
• CPC Class Codes: A61M 15/0085 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 2016/0024 with an on-off output signal, e.g. from a switch

Abstract

Devices and methods for nebulizing a fluid are described. A replaceable fluid assembly may include a reservoir and a fluid cartridge. The reservoir may be detachable from the fluid cartridge and may be assembled by the prior prior to loading into the nebulizing device.

Claims

1. A method of delivering a nebulized fluid for inhalation, comprising the steps of:

providing a nebulizing device, a reservoir and a container, the reservoir and container being adapted for holding volumes of fluids and being replaceable;

delivering a volume of fluid corresponding to a selected dose size from the container to the reservoir;

transferring the volume of fluid from the reservoir to the nebulizing device;

using the nebulizing device to nebulize the volume of fluid;

repeating the delivering and using steps a number of times with the same container;

removing and replacing the container; and

removing and replacing the reservoir.

2. The method of claim 1, wherein:

the providing step is carried out with the nebulizing device having a vibrating element with a plurality of holes, the reservoir holding a fluid in contact with the vibrating element.

3. The method of claim 1, wherein:

the removing and replacing steps are carried out with the reservoir being mounted to the container by the user which is followed by the user mounting both components together into the nebulizing device.

4. The method of claim 1, wherein:

the providing step is carried out with reservoir having a needle which penetrates the container thereby providing a fluid path between the container and the reservoir.

5. The method of claim 1, wherein:

the providing step is carried out with a one-way valve positioned along a fluid path between the container and the reservoir.

6. The method of claim 5, wherein:

the providing step is carried out with the nebulizing device having a vibrating assembly, the vibrating assembly having a plurality of holes therein; and

the delivering step is carried out with the valve directing the fluid at the vibrating assembly; and

the using step is carried out with the fluid passing through the holes in the vibrating assembly.

7. The method of claim 5, wherein:

the delivering step is carried out with the valve delivering a stream of the fluid.

8. The method of claim 7, wherein:

the delivering step is carried out with the stream of fluid being directed at a vibrating assembly of the nebulizing device.

9. The method of claim 5, wherein:

the providing step is carried out with the valve positioned at the end of the fluid path so that the valve leads directly into the reservoir.

10. The method of claim 1, further comprising the step of:

removing a mouthpiece before the removing steps to permit at least one of the reservoir and the container to be removed and replaced.

11. The method of claim 10, wherein:

the removing steps are carried out with the reservoir and the container being separate units.

12. The method of claim 11, wherein:

the removing steps are carried out with the reservoir being mounted to the container by the user.