System for multiple sterile sample collection and isolation

• US 6,852,288 B2
• Filed: 08/02/2001
• Issued: 02/08/2005
• Est. Priority Date: 08/02/2000
• Status: Expired due to Fees

• Current Assignee: NLT Technologies, Ltd.
• Original Assignee: NLT Technologies, Ltd.
• Inventors: Newberg, Douglas A.
• Primary Examiner(s): Warden, Jill
• Assistant Examiner(s): Cross, LaToya I.
• Application Number:
  US09/919,836
• Publication Number:
  US 20020041830A1
• Time in Patent Office: 1,286 Days
• Field of Search: 422/100, 422102-104, 422/26, 422/28, 436/43, 436/47, 436/49, 436/180, 738/63, 738/639.5, 738/637.1, 738/64, 738/642.3, 738/634.5
• US Class Current: 73/863.71
• CPC Class Codes: B01L 2300/0672 Integrated piercing tool
• CPC Class Codes: B01L 3/0293 for liquids
• CPC Class Codes: B01L 3/50825 Closing or opening means, corks, bungs closures for containers B65D; means for removing stoppers B67B7/02
• CPC Class Codes: B01L 9/50 Clamping means, tongs in general F16B2/06
• CPC Class Codes: G01N 1/10 in the liquid or fluent state burettes, pipettes B01L3/02; sampling of ground water E02D1/06; metering by volume of fluids or fluent solid material G01F11/00, G01F13/00
• CPC Class Codes: G01N 1/18 with provision for splitting samples into portions G01N1/12, G01N1/14 take precedence; fraction-collection apparatus for chromatography B01D15/08
• CPC Class Codes: G01N 2001/1012 Suspensions
• CPC Class Codes: G01N 2001/2071 Removable sample bottle
• CPC Class Codes: G01N 2035/00277 Special precautions to avoid contamination (e.g. enclosures, glove- boxes, sealed sample carriers, disposal of contaminated material)
• CPC Class Codes: Y10T 436/11 Automated chemical analysis
• CPC Class Codes: Y10T 436/113332 with conveyance of sample along a test line in a container or rack
• CPC Class Codes: Y10T 436/114165 with step of insertion or removal from test line
• CPC Class Codes: Y10T 436/114998 with treatment or replacement of aspirator element [e.g., cleaning, etc.]
• CPC Class Codes: Y10T 436/2575 Volumetric liquid transfer

Abstract

This device is directed at filling multiple receptacles without losing integrity of the system. It is also directed at receiving a (sealed) container of receptacles (opened or stopper/closed), opening an access into the sealed container, retrieving receptacles, filling those receptacles, stoppering the receptacles after filling and ejecting the receptacles, either directly into the outside environment or into a closable sack or container, in the latter case while maintaining the integrity of the environment within the device and, if desirable, the sack or closed container.

Claims

1. A device for collecting samples from within a sealed system, comprising:

a housing, said housing having an internal cavity sealed from the ambient environment outside the housing;

a plurality of receptacles, each of said plurality of receptacles being movable into said internal cavity of said housing and fillable with a flowable material while within said internal cavity of said housing, respectively; and

a filled receptacle holder, said filled receptacle holder receiving each of said plurality of receptacles after each of said plurality of receptacles has been filled, said filled receptacle holder being sealed with said housing to form a barrier between the environment within said internal cavity of said housing and the ambient environment outside said housing,

wherein said filled receptacle holder is an integral tube which is separable into a plurality of filled receptacle compartments, a first of said plurality of compartments having an open end thereof forming a seal with said housing, and a last of said plurality of compartments having a closed distal end, each of said plurality of compartments being closable to contain at least one of said plurality of filled receptacles therein in an isolated manner.

2. The device for collecting samples from within a sealed system according to claim 1, wherein said last of said plurality of compartments is closable after a first of said plurality of filled receptacles is received therein to isolate said first filled receptacle from the environment within said internal cavity of said housing and from said ambient environment outside the housing, remaining of said plurality of compartments remaining in an open condition with said internal cavity of said housing to receive a subsequent filled receptacle therein.

3. The device for collecting samples from within a sealed system according to claim 2, wherein each of said plurality of compartments is closable at opposite ends thereof to isolate adjacent of said plurality of compartments from each other when a respective of said plurality of compartments has received a filled receptacle therein.

4. The device for collecting samples from within a sealed system according to claim 2, wherein each of said plurality of compartments is closable by one of the group consisting of heat sealing, zipper sealing, crimping, adhesive sealing, screw capping, twisting, sonicating, tying off, clamping and stoppering.

5. The device for collecting samples from within a sealed system according to claim 1, further comprising a flowable material supplier, said flowable material supplier being operable to supply a flowable material between adjacent of said plurality of compartments when one of said plurality of compartments has been closed to enclose at least one of said plurality of receptacles therein.

6. The device for collecting samples from within a sealed system according to claim 1, further comprising:

an injection port formed in said housing; and

an empty receptacle holder, said empty receptacle holder being in communication with said injection port and being sealed with the housing to form a barrier between the environment within the internal cavity of said housing and the ambient environment outside said housing,

wherein said empty receptacle holder holds said plurality of receptacles therein prior to filling within said housing.

7. The device for collecting samples from within a sealed system according to claim 1, further comprising:

a receptacle conveyor, said receptacle conveyor being movable to transport each of said plurality of receptacles to a filling station within said internal cavity of said housing where each of said plurality of receptacles is fillable, respectively and from said filling station to an ejection port formed in said housing; and

a flowable material feeder having an opening at said filling station within said internal cavity of said housing, said flowable material feeder being operable to feed material from a supply source into each of said plurality of receptacles.

8. The device for collecting samples from within a sealed system according to claim 7, further comprising a stopper removing or opening mechanism, said stopper removing or opening mechanism being operable to remove or open a stopper from each of said plurality of receptacles when each of said plurality of receptacles is located at said filling station to allow for each of said plurality of receptacles to be filled by said flowable material feeder.

9. The device for collecting samples from within a sealed system according to claim 8, wherein said stopper removing or opening mechanism is operable to remove a screw-on or plug stopper from each of said plurality of receptacles, open a port in each of said plurality of receptacles, or penetrate a septum on each of said plurality of receptacles.

10. The device for collecting samples from within a sealed system according to claim 8, further comprising a stopper attaching mechanism, said stopper attaching mechanism being operable to attach a screw-on or plug stopper to each of said plurality of receptacles, close a port in each of said plurality of receptacles, or close or seal a penetrated septum on each of said plurality of receptacles.

11. The device for collecting samples from within a sealed system according to claim 1, further comprising:

a flowable material feeder, said flowable material feeder being operable to feed material into each of said plurality of receptacles; and

a flowable material supplier, said flowable material supplier being operable to supply a flowable material into said filled receptacle holder.

12. A device for collecting samples from within a sealed system, comprising:

a housing, said housing having an internal cavity sealed from the ambient environment outside the housing, said housing including an injection port and an ejection port formed therein;

an empty receptacle holder, said empty receptacle holder being in communication with said injection port and being sealed with said housing to form a barrier between the environment within the internal cavity of said housing and the ambient environment outside said housing, said empty receptacle holder holding a plurality of receptacles therein;

a filled receptacle holder, said filled receptacle holder being in communication with said ejection port and being sealed with said housing to form a barrier between the environment within the internal cavity of said housing and the ambient environment outside said housing, said filled receptacle holder for receiving said plurality of receptacles therein and being removably mounted to said housing such that the environment inside said housing and the environment inside said filled receptacle holder remain sealed from each other and the ambient environment outside the housing when said filled receptacle holder and said housing are removed from each other,

wherein each of said plurality of receptacles is movable from said empty receptacle holder into said internal cavity of said housing to be filled with a flowable material while within said internal cavity of said housing, and said plurality of receptacles is movable into said filled receptacle holder to be removed therewith, and

wherein said filled receptacle holder is an integral tube which is separable into a plurality of filled receptacle compartments, a first of said plurality of compartments having an open end thereof forming a seal with said housing, and a last of said plurality of compartments having a closed distal end, each of said plurality of compartments being closable to contain at least one of said plurality of receptacles therein in an isolated manner.

13. The device for collecting samples from within a sealed system according to claim 12, wherein said last of said plurality of compartments is closable after a first of said plurality of filled receptacles is received therein to isolate said first filled receptacle from the environment within said internal cavity of said housing and from said ambient environment outside said housing, remaining of said plurality of compartments remaining in an open condition with said internal cavity of said housing to receive a subsequent filled receptacle therein.

14. The device for collecting samples from within a sealed system according to claim 13, wherein each of said plurality of compartments is closable at opposite ends thereof to isolate adjacent of said plurality of compartments from each other when a respective of said plurality of compartments has received a filled receptacle therein.

15. The device for collecting samples from within a sealed system according to claim 13, wherein each of said plurality of compartments is closable by one of the group consisting of heat sealing, zipper sealing, crimping, adhesive sealing, screw capping, twisting, sonicating, tying off, clamping and stoppering.

16. A device for collecting samples from within a sealed system, comprising:

a housing, said housing having an internal cavity sealed from the ambient environment outside the housing, said housing including an injection port and an ejection port formed therein;

an empty receptacle holder, said empty receptacle holder being in communication with said injection port and being sealed with said housing to form a barrier between the environment within the internal cavity of said housing and the ambient environment outside said housing, said empty receptacle holder holding at least one receptacle therein;

a filled receptacle holder, said filled receptacle holder being in communication with said ejection port and being sealed with said housing to form a barrier between the environment within the internal cavity of said housing and the ambient environment outside said housing, said filled receptacle holder for receiving said at least one receptacle therein and being removably mounted to said housing such that the environment inside said housing and the environment inside said filled receptacle holder remain sealed from each other and the ambient environment outside the housing when said filled receptacle holder and said housing are removed from each other,

a receptacle conveyor, said receptacle conveyor being movable to transport each of said at least one receptacle to a filling station within said internal cavity of said housing where each of said at least one receptacle is fillable and from said filling station to said ejection port formed in said housing;

a flowable material feeder having an opening at said filling station within said internal cavity of said housing, said flowable material feeder being operable to feed material from a supply source into each of said at least one receptacle;

a stopper removing or opening mechanism, said stopper removing or opening mechanism being operable to remove or open a stopper from each of said at least one receptacle when each of said at least one receptacle is located at said filling station to allow for each of said at least one receptacle to be filled by said flowable material feeder; and

a stopper attaching mechanism, said stopper attaching mechanism being operable to attach a screw-on or plug stopper to each of said at least one receptacle, close a port in each of said at least one receptacle, or close or seal a penetrated septum on each of said at least one receptacles,

wherein each of said at least one receptacle is movable from said empty receptacle holder into said internal cavity of said housing to be filled with a flowable material while within said internal cavity of said housing, and said at least one receptacle is movable into said filled receptacle holder to be removed therewith.

17. A device for collecting samples from within a sealed system, comprising:

a housing, said housing having an internal cavity sealed from the ambient environment outside the housing, said housing including an injection port and an ejection port formed therein;

an empty receptacle holder, said empty receptacle holder being in communication with said injection port and being sealed with said housing to form a barrier between the environment within the internal cavity of said housing and the ambient environment outside said housing, said empty receptacle holder holding a plurality of receptacles therein;

a filled receptacle holder, said filled receptacle holder being in communication with said ejection port and being sealed with said housing to form a barrier between the environment within the internal cavity of said housing and the ambient environment outside said housing, said filled receptacle holder for receiving each of said plurality of receptacle therein and being removably mounted to said housing such that the environment inside said housing and the environment inside said filled receptacle holder remain sealed from each other and the ambient environment outside the housing,

wherein said filled receptacle holder is an integral tube which is separable into a plurality of filled receptacle compartments, a first of said plurality of compartments having an open end thereof forming a seal with said housing, and a last of said plurality of compartments having a closed distal end, each of said plurality of compartments being closable to contain at least one of said plurality of receptacles therein in an isolated manner, and

wherein each of said plurality of receptacles is movable from said empty receptacle holder into said internal cavity of said housing to be filled with a flowable material while within said internal cavity of said housing, and each of said plurality of receptacles is movable into said filled receptacle holder to be removed therewith.

18. The device for collecting samples from within a sealed system according to claim 17, wherein said last of said plurality of compartments is closable after a first of said plurality of filled receptacles is received therein to isolate said first filled receptacle from the environment within said internal cavity of said housing and from said ambient environment outside said housing, remaining of said plurality of compartments remaining in an open condition with said internal cavity of said housing to receive a subsequent filled receptacle therein.

19. The device for collecting samples from within a sealed system according to claim 18, wherein each of said plurality of compartments is closable at opposite ends thereof to isolate adjacent of said plurality of compartments from each other when a respective of said plurality of compartments has received a filled receptacle therein.

20. The device for collecting samples from within a sealed system according to claim 18, wherein each of said plurality of compartments is closable by one of the group consisting of heat sealing, zipper sealing, crimping, adhesive sealing, screw capping, twisting, sonicating, tying off, clamping and stoppering.