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Identifying a base in a nucleic acid

  • US 6,852,488 B2
  • Filed: 02/06/2001
  • Issued: 02/08/2005
  • Est. Priority Date: 06/25/1993
  • Status: Expired due to Fees
First Claim
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1. A method of detecting a mutation in a target nucleic acid sequence versus a known sequence comprising:

  • a) exposing the target sequence to at least one known core sequence probe;

    b) determining the binding affinity of the target sequence to the at least one known core sequence probe;

    c) determining the binding affinity of the target sequence to at least one probe that has a single nucleotide variation as compared to the at least one known core sequence probe; and

    d) comparing the binding affinity determined in step b) to the binding affinity determined in step c);

    thereby detecting a mutation in a target nucleic acid sequence versus a known sequence.

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