Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using oxazolidinone derivatives
First Claim
Patent Images
1. A process of synthesizing N-[N-(3,3-dimethylbutyl)-L-α
- -aspartyl]-L-phenylalanine 1-methyl ester comprising the steps of;
(a) reacting an admixture of (i) N-(3,3-dimethylbutyl)-L-aspartic acid and (ii) a ketone or an acetal of a ketone in a solvent for a time and at a temperature sufficient to produce an oxazolidinone derivative; and
(b) reacting an admixture of the oxazolidinone derivative and L-phenylalanine or L-phenylalanine methyl ester in the solvent for a time and at a temperature sufficient to produce N-[N-(3,3-dimethylbutyl)-L-α
-aspartyl]-L-phenylalanine 1-methyl ester.
10 Assignments
0 Petitions
Accused Products
Abstract
Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester by treating N-(3,3-dimethylbutyl)-L-aspartic acid with ketones to give oxazolidinone derivatives, which are condensed with L-phenylalanine methyl ester.
50 Citations
18 Claims
-
1. A process of synthesizing N-[N-(3,3-dimethylbutyl)-L-α
- -aspartyl]-L-phenylalanine 1-methyl ester comprising the steps of;
(a) reacting an admixture of (i) N-(3,3-dimethylbutyl)-L-aspartic acid and (ii) a ketone or an acetal of a ketone in a solvent for a time and at a temperature sufficient to produce an oxazolidinone derivative; and
(b) reacting an admixture of the oxazolidinone derivative and L-phenylalanine or L-phenylalanine methyl ester in the solvent for a time and at a temperature sufficient to produce N-[N-(3,3-dimethylbutyl)-L-α
-aspartyl]-L-phenylalanine 1-methyl ester. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
- -aspartyl]-L-phenylalanine 1-methyl ester comprising the steps of;
Specification