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Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using oxazolidinone derivatives

  • US 6,852,875 B2
  • Filed: 05/18/2001
  • Issued: 02/08/2005
  • Est. Priority Date: 05/19/2000
  • Status: Expired due to Term
First Claim
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1. A process of synthesizing N-[N-(3,3-dimethylbutyl)-L-α

  • -aspartyl]-L-phenylalanine 1-methyl ester comprising the steps of;

    (a) reacting an admixture of (i) N-(3,3-dimethylbutyl)-L-aspartic acid and (ii) a ketone or an acetal of a ketone in a solvent for a time and at a temperature sufficient to produce an oxazolidinone derivative; and

    (b) reacting an admixture of the oxazolidinone derivative and L-phenylalanine or L-phenylalanine methyl ester in the solvent for a time and at a temperature sufficient to produce N-[N-(3,3-dimethylbutyl)-L-α

    -aspartyl]-L-phenylalanine 1-methyl ester.

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