Administration of anti-inflammatory drugs into the central nervous system
First Claim
1. A method for delivering a Non Steroidal Anti-Inflammatory Drug (NSAID) to at least a portion of a central nervous system (CNS) of a subject, comprising:
- supplying the NSAID to a systemic blood circulation of the subject;
stimulating at least one site of the subject, the site selected from the list consisting of;
a sphenopalatine ganglion (SPG) of the subject, an anterior ethmoidal nerve of the subject, a posterior ethmoidal nerve of the subject, a communicating branch between an anterior ethmoidal nerve and a retro-orbital branch of an SPG of the subject, a communicating branch between a posterior ethmoidal nerve and a retro-orbital branch of an SPG of the subject, a greater palatine nerve of the subject, a lesser palatine nerve of the subject, a sphenopalatine nerve of the subject, a communicating branch between a maxillary nerve and an SPG of the subject, a nasopalatine nerve of the subject, a posterior nasal nerve of the subject, an infraorbital nerve of the subject, an otic ganglion of the subject, an afferent fiber going into the otic ganglion of the subject, an efferent fiber going out of the otic ganglion of the subject, a vidian nerve of the subject, a greater superficial petrosal nerve of the subject, and a lesser deep petrosal nerve of the subject; and
configuring the stimulation so as to cause an increase in passage of the NSAID from the systemic blood circulation across a blood brain barrier (BBB) of the subject to the portion of the CNS, during at least a portion of the time that the NSAID is present in the blood.
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Accused Products
Abstract
Apparatus is provided for delivering a Non Steroidal Anti-Inflammatory Drug (NSAID) supplied to a body of a subject for delivery to at least a portion of a central nervous system (CNS) of the subject via a systemic blood circulation of the subject, including a stimulator adapted to stimulate at least one site of the subject, so as to cause an increase in passage of the NSAID from the systemic blood circulation across a blood brain barrier (BBB) of the subject to the portion of the CNS, during at least a portion of the time that the NSAID is present in the blood, the site selected from the list consisting of: a sphenopalatine ganglion (SPG) of the subject, an anterior ethmoidal nerve of the subject, a posterior ethmoidal nerve of the subject, a communicating branch between an anterior ethmoidal nerve and a retro-orbital branch of an SPG of the subject, a communicating branch between a posterior ethmoidal nerve and a retro-orbital branch of an SPG of the subject, a greater palatine nerve of the subject, a lesser palatine nerve of the subject, a sphenopalatine nerve of the subject, a communicating branch between a maxillary nerve and an SPG of the subject, a nasopalatine nerve of the subject, a posterior nasal nerve of the subject, an infraorbital nerve of the subject, an otic ganglion of the subject, an afferent fiber going into the otic ganglion of the subject, an efferent fiber going out of the otic ganglion of the subject, a vidian nerve of the subject, a greater superficial petrosal nerve of the subject, and a lesser deep petrosal nerve of the subject.
127 Citations
44 Claims
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1. A method for delivering a Non Steroidal Anti-Inflammatory Drug (NSAID) to at least a portion of a central nervous system (CNS) of a subject, comprising:
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supplying the NSAID to a systemic blood circulation of the subject;
stimulating at least one site of the subject, the site selected from the list consisting of;
a sphenopalatine ganglion (SPG) of the subject, an anterior ethmoidal nerve of the subject, a posterior ethmoidal nerve of the subject, a communicating branch between an anterior ethmoidal nerve and a retro-orbital branch of an SPG of the subject, a communicating branch between a posterior ethmoidal nerve and a retro-orbital branch of an SPG of the subject, a greater palatine nerve of the subject, a lesser palatine nerve of the subject, a sphenopalatine nerve of the subject, a communicating branch between a maxillary nerve and an SPG of the subject, a nasopalatine nerve of the subject, a posterior nasal nerve of the subject, an infraorbital nerve of the subject, an otic ganglion of the subject, an afferent fiber going into the otic ganglion of the subject, an efferent fiber going out of the otic ganglion of the subject, a vidian nerve of the subject, a greater superficial petrosal nerve of the subject, and a lesser deep petrosal nerve of the subject; and
configuring the stimulation so as to cause an increase in passage of the NSAID from the systemic blood circulation across a blood brain barrier (BBB) of the subject to the portion of the CNS, during at least a portion of the time that the NSAID is present in the blood. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44)
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Specification
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- Resources
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Current AssigneeBrainsGate Ltd.
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Original AssigneeBrainsGate Ltd.
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InventorsShalev, Alon
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Primary Examiner(s)Bockelman, Mark
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Application NumberUS10/294,343Publication NumberTime in Patent Office817 DaysField of Search607/3, 607/45, 607/46, 604/20, 604/522, 604/514, 604/94.01, 128/200.14US Class Current607/3CPC Class CodesA61M 2205/3303 Using a biosensorA61M 2210/0618 NoseA61M 2210/0693 Brain, cerebrumA61M 5/14276 specially adapted for impla...A61M 5/1723 using feedback of body para...A61N 1/0526 Head electrodes A61N1/0551 ...A61N 1/0546 Nasal electrodesA61N 1/0548 Oral electrodesA61N 1/205 for promoting a biological ...A61N 1/325 for iontophoresis, i.e. tra...A61N 1/36017 with leads or electrodes pe...A61N 1/3605 Implantable neurostimulator...A61N 1/36071 PainA61N 1/36082 Cognitive or psychiatric ap...
