Transdermal perfusion of fluids
First Claim
1. A method of transdermal administration of fluids through the skin of a human or animal body, comprising the steps of:
- attaching a housing to the body such that a contact surface of the housing is held in contact with a portion of skin by an adhesive layer, the housing defining a chamber and the contact surface defining an aperture communicating with the chamber;
applying suction to the skin at a treatment site which is accessible via the aperture until an area of the skin'"'"'s epidermis at the treatment site is detached from the skin'"'"'s underlying dermis;
disrupting the detached area of epidermis such that the dermis is exposed within the chamber; and
supplying fluid to the chamber such that the fluid may be absorbed by the dermis without intervention of the epidermis.
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Accused Products
Abstract
A housing is secured to an area of skin to allow suction to be applied to a local area of skin through an aperture. After formation of a suction blister, a blade is actuated to sever a suction cup thereby detaching the means for creating suction at the aperture and at the same time removing the roof of the suction blister to expose an area of dermis from which the skin'"'"'s epidermis has been removed.
A rotatable portion of the apparatus is then moved into a position in which a port communicates with a compartment within the rotatable portion. The compartment may contain a reservoir of fluid substance to be transdermally absorbed or may contain means for taking a sample of exudate produced at the exposed dermis. A modified apparatus has means for applying suction to the exposed dermis to enhance the rate at which exudate is formed and for handling a sample of exudate for analysis. Transdermal delivery and sampling are thereby achieved non-invasively and without the impediment of the skin'"'"'s epidermis.
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Citations
1 Claim
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1. A method of transdermal administration of fluids through the skin of a human or animal body, comprising the steps of:
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attaching a housing to the body such that a contact surface of the housing is held in contact with a portion of skin by an adhesive layer, the housing defining a chamber and the contact surface defining an aperture communicating with the chamber;
applying suction to the skin at a treatment site which is accessible via the aperture until an area of the skin'"'"'s epidermis at the treatment site is detached from the skin'"'"'s underlying dermis;
disrupting the detached area of epidermis such that the dermis is exposed within the chamber; and
supplying fluid to the chamber such that the fluid may be absorbed by the dermis without intervention of the epidermis.
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Specification