Delivery of analgesics through an inhalation route
First Claim
1. A composition for delivery of acetaminophen, orphenadrine or tramadol comprising a condensation aerosola) formed by volatilizing acetaminophen, orphenadrine or tramadol under conditions effective to produce a heated vapor of acetaminophen, orphenadrine or tramadol and condensing the heated vapor of the acetaminophen, orphenadrine or tramadol to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% acetaminophen, orphenadrine or tramadol degradation products, and c) wherein the aerosol MMAD is less than 3 microns.
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Accused Products
Abstract
The present invention relates to the delivery of analgesics through an inhalation route. Specifically, it relates to aerosols containing acetaminophen, orphenadrine or tramadol that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of acetaminophen, orphenadrine or tramadol. In a method aspect of the present invention, one of acetaminophen, orphenadrine or tramadol is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of acetaminophen, orphenadrine or tramadol, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering acetaminophen, orphenadrine or tramadol through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of acetaminophen, orphenadrine or tramadol; and, b) a device that forms an acetaminophen, orphenadrine or tramadol containing aerosol from the composition, for inhalation by the mammal.
175 Citations
12 Claims
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1. A composition for delivery of acetaminophen, orphenadrine or tramadol comprising a condensation aerosol
a) formed by volatilizing acetaminophen, orphenadrine or tramadol under conditions effective to produce a heated vapor of acetaminophen, orphenadrine or tramadol and condensing the heated vapor of the acetaminophen, orphenadrine or tramadol to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% acetaminophen, orphenadrine or tramadol degradation products, and c) wherein the aerosol MMAD is less than 3 microns.
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6. A method of producing an analgesic in an aerosol form comprising:
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a) volatilizing an analgesic under conditions effective to produce a heated vapor of the analgesic, and b) during said volatilizing, passing air through the heated vapor to produce aerosol particles of the analgesic comprising less than 5% analgesic degradation products and an aerosol having an MMAD less than 3 μ
m. - View Dependent Claims (7, 8, 9, 10, 11)
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12. A composition for delivery of an analgesic comprising a condensation aerosol
a) formed by volatilizing an analgesic under conditions effective to produce a heated vapor of the analgesic and condensing the heated vapor of the analgesic to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% analgesic degradation products, and c) wherein the aerosol MMAD is less than 3 microns.
Specification