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Sustained release hydrophobic bioactive PLGA microspheres

  • US 6,855,331 B2
  • Filed: 06/10/2002
  • Issued: 02/15/2005
  • Est. Priority Date: 05/16/1994
  • Status: Expired due to Fees
First Claim
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1. A method of preparing a controlled release microcapsule pharmaceutical composition of burst-free sustained, programmable release of a hydrophobic bioactive agent over a duration of 24 hours to 100 days, comprising the steps of:

  • a) mixing a hydrophobic bioagent with a blend of end-capped and uncapped biocompatible, biodegradable poly(lactide/glycolide) copolymer, wherein said end-capped polymer has terminal residues functionalized as esters and said uncapped polymer has terminal residues existing as carboxylic acids; and

    b) performing a solvent evaporation process to form said microcapsules.

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