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Human RNase H1 mutants

  • US 6,855,530 B2
  • Filed: 11/14/2001
  • Issued: 02/15/2005
  • Est. Priority Date: 11/15/2000
  • Status: Expired due to Fees
First Claim
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1. A human RNase H1 polypeptide which comprises a mutation compared to wild type human RNase H1, wherein said mutation produces a mutant version of human RNase H1 polypeptide that consists of a deletion mutation of region I, a deletion mutation of region II, a deletion mutation of region I and region II, or a lysine-to-alanine substitution at amino acids 226 and 227 of SEQ ID NO:

  • 3, and wherein said mutant version retains detectable cleavage activity for the RNA strand of an RNA/DNA duplex.

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