Ketamine treatment of restless legs syndrome

• US 6,855,735 B2
• Filed: 03/20/2002
• Issued: 02/15/2005
• Est. Priority Date: 03/20/2002
• Status: Expired due to Fees

• Current Assignee: Temple University of The Commonwealth System of Higher Education
• Original Assignee: Temple University of The Commonwealth System of Higher Education
• Inventors: Friedman, Robert
• Primary Examiner(s): Kunz, Gary
• Assistant Examiner(s): LANDAU, SHARMILA GOLLAMUDI
• Application Number:
  US10/102,374
• Publication Number:
  US 20030181528A1
• Time in Patent Office: 1,063 Days
• Field of Search: 514/183, 514/289, 514/450, 514/654, 514/658, 514/816, 514/944, 514/964, 514/647, 514/935, 424/400, 424/422, 424/440, 424/451, 424/457, 424/464, 424/468, 424/78.02, 424/78.05
• US Class Current: 514/647
• CPC Class Codes: A61K 31/135 having aromatic rings , e.g. ketamine, nortriptyline methadone A61K31/137

Abstract

The present invention is directed to a method for treating symptoms associated with Restless Legs Syndrome (RLS). The method includes administering to a warm-blooded animal in need of such treatment a dose of ketamine sufficient to alleviate symptoms associated with RLS.

Claims

1. A method for treating Restless Legs Syndrome in a warm-blooded animal comprising administering to the warm-blooded animal a subanalgesic dose of ketamine insufficient to induce psychotomimetic side effects, such that motor restlessness, insomnia, and limb sensations associated with Restless Legs Syndrome are alleviated, said limb sensations being characterized by sensations of pulling, drawing, crawling, wormy, boring, tingling, pins and needles, or prickly.

2. The method according to claim 1, wherein the dose of ketamine is administered orally.

3. The method according to claim 2, wherein the dose of ketamine is less than about 0.1 mg/kg of body weight.

4. The method according to claim 1, wherein the dose of ketamine produces a serum level of ketamine in the warm-blooded animal of no more than about 50 ng/ml.

5. The method according to claim 1, wherein the warm blooded animal is a human.

6. The method according to claim 2, wherein the oral dose of ketamine is administered in a form selected from the group consisting of a powder, a tablet, a capsule, a pill, a lozenge, a sustained release form, a liquid, a suspension, and a gel.