Implantable microfluidic delivery system using ultra-nanocrystalline diamond coating
First Claim
1. A microfluidic delivery system for the transport of molecules comprising:
- a substrate;
a reservoir in said substrate for containing the molecules;
a fluid control device controlling release of said molecules from said reservoir; and
a thin film inert impermeable coating applied to said substrate.
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Accused Products
Abstract
An implantable biocompatible microchip drug delivery substrate is coated with a thin film of ultra-nanocrystalline diamond; assuring that the device is biocompatible and impermeably sealed, to prevent the substrate from being dissolved by the living tissue and to protect the drugs from premature release or undesired reaction with the body fluids. The coating is selectively patterned by doping to create electrically conductive areas that can be used as an electrically activated release mechanism for drug delivery. The conformal ultra-nanocrystalline diamond coating uniformly covers the device, providing relief from sharp edges and producing a strong, uniformly thick impermeable coating around sharp edges and on high aspect-ratio parts. The ultra-nanocrystalline diamond coating provides a conformal coating on the biocompatible device, which is of approximately uniform thickness around sharp corners and on high aspect-ratio parts. The conformal nature of the coating assures impermeability and strength despite the presence of difficult to coat shapes.
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Citations
28 Claims
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1. A microfluidic delivery system for the transport of molecules comprising:
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a substrate;
a reservoir in said substrate for containing the molecules;
a fluid control device controlling release of said molecules from said reservoir; and
a thin film inert impermeable coating applied to said substrate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A microfluidic delivery system for the release of molecules comprising:
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a substrate;
at least one reservoir in the substrate that is suitable to contain the molecules;
the reservoir having a reservoir cap positioned on the reservoir over the molecules;
wherein release of the molecules from the reservoir is controlled by said reservoir cap; and
whereinwherein said substrate is coated with a thin film of ultra-nanocrystalline diamond deposited on said biocompatible device wherein said thin film forms a biocompatible impermeably sealed substrate. - View Dependent Claims (24, 25, 26, 27, 28)
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Specification
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- Resources
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Current AssigneeSecond Sight Medical Products, Inc. (Vivani Medical, Inc.)
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Original AssigneeSecond Sight Medical Products, Inc. (Vivani Medical, Inc.)
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InventorsGreenberg, Robert J., Mech, Brian V.
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Primary Examiner(s)AZPURU, CARLOS A
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Application NumberUS10/046,458Publication NumberTime in Patent Office1,215 DaysField of Search424/422, 424/423US Class Current424/423CPC Class CodesA61K 9/0009 involving or responsive to ...A61K 9/0097 Micromachined devices; Micr...B82Y 30/00 Nanotechnology for material...C23C 16/274 using microwave dischargesC23C 16/277 using other elements in the...C23C 16/278 doping or introduction of a...C23C 16/279 control of diamond crystall...
