Intravascular delivery of mycophenolic acid
First Claim
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1. A method for inhibiting restenosis in a blood vessel following recanalization of the blood vessel, said method comprising:
- implanting a vascular prosthesis having means thereon or therein for releasing mycophenolic acid in the blood vessel; and
releasing mycophenolic acid from the prosthesis into the blood vessel so as to inhibit smooth muscle cell proliferation.
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Abstract
The present invention provides improved devices and methods for minimizing and/or inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides luminal prostheses which allow for programmed and controlled mycophenolic acid delivery with increased efficacy to selected locations within a patient'"'"'s vasculature to inhibit restenosis. An intraluminal delivery prosthesis may comprise an expansible structure and means on or within the structure for releasing mycophenolic acid at a rate selected to inhibit smooth muscle cell proliferation.
157 Citations
40 Claims
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1. A method for inhibiting restenosis in a blood vessel following recanalization of the blood vessel, said method comprising:
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implanting a vascular prosthesis having means thereon or therein for releasing mycophenolic acid in the blood vessel; and
releasing mycophenolic acid from the prosthesis into the blood vessel so as to inhibit smooth muscle cell proliferation. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 24)
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2. A method for inhibiting restenosis in a blood vessel following recanalization of the blood vessel, said method comprising:
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implanting a vascular prosthesis in the blood vessel; and
releasing mycophenolic acid at a rate between 5 μ
g/day to 200 μ
g/day to inhibit smooth muscle cell proliferation.
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16. A method for inhibiting restenosis in a blood vessel following recanalization of the blood vessel, said method comprising:
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implanting a vascular prosthesis having means thereon or therein for releasing mycophenolic acid in the blood vessel; and
releasing mycophenolic acid and at least one other substance in addition to mycophenolic acid from the prosthesis when implanted in the blood vessel so as to inhibit smooth muscle cell proliferation. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23)
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25. A method for inhibiting restenosis in a blood vessel following recanalization of the blood vessel, said method comprising:
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implanting a vascular prosthesis having a barrier thereon for releasing mycophenolic acid in the blood vessel; and
releasing mycophenolic acid from the prosthesis barrier into the blood vessel so as to inhibit smooth muscle cell proliferation. - View Dependent Claims (26, 27)
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28. A method for inhibiting restenosis in a blood vessel following recanalization of the blood vessel, said method comprising:
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implanting a vascular prosthesis having a matrix thereon for releasing mycophenolic acid in the blood vessel; and
releasing mycophenoli acid from the prosthesis matrix into the blood vessel so as to inhibit smooth muscle cell proliferation.
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29. A method for inhibiting restenosis in a blood vessel following recanalization of the blood vessel, said method comprising:
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implanting a vascular prosthesis having a reservoir and a cover thereon for releasing mycophenolic acid in the blood vessel; and
releasing mycophenolic acid from the prosthesis reservoir into the blood vessel so as to inhibit smooth muscle cell proliferation.
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30. A method for inhibiting restenosis in a blood vessel following recanalization of the blood vessel, said method comprising:
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implanting a vascular prosthesis having a reservoir and a cover thereon in the blood vessel; and
releasing mycophenolic acid from the prosthesis reservoir into the blood vessel so as to inhibit smooth muscle cell proliferation by directing energy from an external energy source at the prosthesis reservoir. - View Dependent Claims (31)
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32. A method for inhibiting restenosis in a blood vessel following recanalization of the blood vessel, said method comprising:
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implanting a vascular prosthesis in the blood vessel; and
releasing mycophenolic acid from the prosthesis into the blood vessel so as to inhibit smooth muscle cell proliferation by directing a magnetic field from an external magnetic source at the prosthesis, wherein the mycophenolic acid is coupled to magnetic particles.
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33. A vascular prosthesis comprising:
an expansible structure which is implantable within a body lumen; and
barrier on or within the structure for releasing mycophenolic acid so as to inhibit smooth muscle cell proliferation. - View Dependent Claims (34, 35)
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36. A vascular prosthesis comprising:
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an expansible structure which is implantable within a body lumen; and
a matrix on or within the structure for releasing mycophenolic acid so as to inhibit smooth muscle cell proliferation.
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37. A vascular prosthesis comprising:
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an expansible structure which is implantable within a body lumen; and
a reservoir on or within the structure and a cover thereon for releasing mycophenolic acid so as to inhibit smooth muscle cell proliferation.
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38. A system prosthesis comprising:
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a vascular prothesis comprising an expansible structure which is implantable within a body lumen;
a reservoir on or within the prothesis and a cover thereon; and
an external energy source for releasing mycophenolic acid from the prothesis reservoir so as to inhibit smooth muscle cell proliferation. - View Dependent Claims (39)
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40. A system comprising:
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a vascular prosthesis comprising an expansible structure which is implantable within a body lumen; and
an external magnetic source for releasing mycophenolic acid from the prosthesis so as to inhibit smooth muscle cell proliferation, wherein the mycophenolic acid is coupled to magnetic particles.
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Specification