Biosensor electromagnetic noise cancellation
First Claim
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1. A Cottrell current-type biosensing cell assembly comprising:
- a. a substrate having a proximal end and a distal end;
b. a measurement loop located on the substrate, the measurement loop including;
i. a pair of spaced-apart conductors each having a proximal end and a distal end, the proximal ends located at the proximal end of the substrate for connection to an instrument, ii. a test cell connected across the distal ends of the conductors, the test cell having an analyte reaction zone with an electrical impedance that varies in response to analyte concentration, the variation in electrical impedance of the analyte reaction zone in response to the application of an analyte, the concentration of which is to be determined, producing a Cottrell current-like profile; and
c. a noise cancellation loop electrically distinct from the analyte reaction zone and physically arranged to be exposed to substantially the same electromagnetic environment as the measurement loop and electrically connected to substantially cancel the effect of electromagnetically propagated field energy irradiating the biosensor cell assembly.
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Abstract
A biosensing cell assembly having a measurement loop with a test cell having an analyte reaction zone for amperometric measurement of a response current to determine analyte concentration and a noise cancellation loop arranged to be physically exposed to the same electromagnetic environment as the measurement loop. The noise cancellation loop has a predetermined impedance within a range of the impedance of the test cell analyte reaction zone and provides a current to cancel or reduce the effects of the electromagnetic environment on the measurement loop.
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Citations
39 Claims
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1. A Cottrell current-type biosensing cell assembly comprising:
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a. a substrate having a proximal end and a distal end;
b. a measurement loop located on the substrate, the measurement loop including;
i. a pair of spaced-apart conductors each having a proximal end and a distal end, the proximal ends located at the proximal end of the substrate for connection to an instrument, ii. a test cell connected across the distal ends of the conductors, the test cell having an analyte reaction zone with an electrical impedance that varies in response to analyte concentration, the variation in electrical impedance of the analyte reaction zone in response to the application of an analyte, the concentration of which is to be determined, producing a Cottrell current-like profile; and
c. a noise cancellation loop electrically distinct from the analyte reaction zone and physically arranged to be exposed to substantially the same electromagnetic environment as the measurement loop and electrically connected to substantially cancel the effect of electromagnetically propagated field energy irradiating the biosensor cell assembly. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method for adjusting the output of a Cottrell current-type biosensing cell assembly comprising:
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a. a substrate having a proximal end and a distal end;
b. a measurement loop located on the substrate, the measurement loop including;
i. a pair of spaced-apart conductors each having a proximal end and a distal end, the proximal ends located at the proximal end of the substrate for connection to an instrument, ii. a test cell connected across the distal ends of the conductors, the test cell having an analyte reaction zone with an electrical impedance that varies in response to analyte concentration, the variation in electrical impedance of the analyte reaction zone in response to the application of an analyte, the concentration of which is to be determined, producing a Cottrell current-like profile;
the method includingc. providing a noise cancellation loop electrically distinct from the analyte reaction zone and physically arranged to be exposed to substantially the same electromagnetic environment as the measurement loop and electrically connected to substantially cancel the effect of electromagnetically propagated field energy irradiating the biosensor cell assembly. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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Specification