Stable radioiodine conjugates and methods for their synthesis
First Claim
1. An aminopolycarboxylate-appended peptide for radioiodinating an antibody selected from the group consisting of:
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(ABG)Gly-D-Tyr-D-Lys(ITC-Bz-DTPA)-OH,(ABG-D-Ala-D-Tyr-D-Tyr-D-Lys)-APC, and(ABG-D-Ala-D-Tyr-D-Tyr-D-Lys)2-APC,
wherein ABG is an antibody binding group, APC is an aminopolycarboxylate, and DTPA is diethylenetriaminepentaacetic acid.
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Abstract
Methods are described for conjugating radioiodinated non-metabolizable peptides to proteins and antibodies with improved yields and qualities of conjugates. Radioiodinated residualizing antibody conjugates comprising any aminopolycarboxylate-appended peptide, or any carbohydrate-appended peptide, are also provided. Additionally, methods are described for conjugating radioiodinated aminopolycarboxylates to proteins and antibodies, as well as for conjugating radioiodinated non-metabolizable carbohydrates to proteins and antibodies by a variety of chemical approaches. The instant radioiodinated residualizing antibody conjugates are particularly stable in vivo and are suitable for radioimmunodetection and radioimmunotherapy.
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Citations
4 Claims
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1. An aminopolycarboxylate-appended peptide for radioiodinating an antibody selected from the group consisting of:
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(ABG)Gly-D-Tyr-D-Lys(ITC-Bz-DTPA)-OH, (ABG-D-Ala-D-Tyr-D-Tyr-D-Lys)-APC, and (ABG-D-Ala-D-Tyr-D-Tyr-D-Lys)2-APC, wherein ABG is an antibody binding group, APC is an aminopolycarboxylate, and DTPA is diethylenetriaminepentaacetic acid. - View Dependent Claims (2, 3, 4)
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Specification