Imaging apparatus and method
First Claim
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1. An apparatus for imaging, comprising:
- a light source emitting a polarized light beam;
a structure having a surface, the light beam from the light source being reflected by the surface to provide an evanescent field, and the surface being adapted to allow placing thereon a specimen array such that the specimen array in the evanescent field causes spatially distributed polarization changes in the cross-section of the light beam; and
a two-dimensional array detector positioned to detect the spatially distributed polarization changes caused by the specimen army.
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Abstract
Imaging apparatus and method which uses change of polarization state of a light beam passed through a total internal reflection structure by a single reflection at a TIR surface in which a specimen is placed in the evanescent field associated with the total internal reflection of the light beam, the specimen being the subject of biological, chemical or genetic investigation.
82 Citations
33 Claims
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1. An apparatus for imaging, comprising:
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a light source emitting a polarized light beam;
a structure having a surface, the light beam from the light source being reflected by the surface to provide an evanescent field, and the surface being adapted to allow placing thereon a specimen array such that the specimen array in the evanescent field causes spatially distributed polarization changes in the cross-section of the light beam; and
a two-dimensional array detector positioned to detect the spatially distributed polarization changes caused by the specimen army. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A method of imaging, comprising:
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passing a polarized light beam into an optical structure for reflection at a surface of the optical structure to provide an evanescent field, a specimen array in the evanescent field causing spatially distributed polarization changes in the cross-section of the light beam;
passing the reflected light beam out of the optical structure;
detecting the spatially distributed polarization changes caused by the specimen array; and
processing the detected spatially distributed polarization changes to provide an image of the specimen array. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33)
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Specification