Method and device for the diagnosis and therapy of chronic heart failure

• US 6,859,662 B2
• Filed: 12/21/2001
• Issued: 02/22/2005
• Est. Priority Date: 12/21/2000
• Status: Active Grant

• Current Assignee: Tonino Bombardini
• Original Assignee: Tonino Bombardini
• Inventors: Bombardini, Tonino
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): BRADFORD, RODERICK D
• Application Number:
  US10/023,761
• Publication Number:
  US 20020091332A1
• Time in Patent Office: 1,159 Days
• Field of Search: 600508-510, 600/453, 600/513, 607/9, 607/23, 607/24
• US Class Current: 600/510
• CPC Class Codes: A61B 5/02 Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives

Abstract

Method and device for the diagnosis and therapy of chronic heart failure comprising continuous monitoring of the patient and continuous determination of significant decompensation parameters during a sample period of normal patient life, recording the data determined, continuously monitoring these data during therapy, comparing the memorized data with those determined during the same time span of the sample period and comparing the duration of periods in which decompensation is present with the total duration of those periods during which decompensation is absent or conforms to that determined during the sample period.

Claims

1. A method for the diagnosis and therapy of chronic heart failure comprising continuous monitoring of the patient and continuous determination of significant decompensation parameters during a sample period of normal patient life, recording the data determined, continuously monitoring these data during therapy, comparing the memorized data with those determined during the same time span of the sample period and comparing the duration of periods in which decompensation is present with the total duration of those periods during which decompensation is absent or conforms to that determined during the sample period, wherein the memorized parameters comprise the curve of ventricular contractile force variation as a function of heart rate.

2. A method as claimed in claim 1, wherein the memorized parameters are the heart rate, the ventricular contractile force, and the curve of force variation as a function of heart rate.

3. A method as claimed in claim 2, wherein the memorized parameters are the heart rate, the ventricular contractile force, and the curve of force variation as a function of heart rate at determined moments of the sample period.

4. A method as claimed in claim 2, in which memorizing the force-frequency curve variations occurs at least during a period equal to the sample period.

5. A method as claimed in claim 2, deriving the force data from the intracardiac pressure curves.

6. A method as claimed in claim 2, deriving the force data from the peripheral pressure curves.

7. A method as claimed in claim 2, deriving the force data from the ventricular volumes.

8. A method as claimed in claim 2, deriving the force data from the pressure/volume relationship.

9. A method as claimed in claim 2, deriving the force data from cardiac tone (force of contraction and/or rate of tension development).

10. A method as claimed in claim 2, deriving the force data via impedance.

11. A method as claimed in claim 2, deriving the force data from Doppler flow measurement.

12. A method as claimed in claim 2, deriving the force data with echo-Doppler.

13. A method as claimed in claim 2, deriving the force data from a combination of all or part of the following parameters:

the intracardiac pressure curves, the peripheral pressure curves, the ventricular volumes, the pressure/volume relationship, the cardiac tone, the impedance, the Doppler flow measurement, the echo-Doppler measurement.

14. A method as claimed in claim 2, expressing the ventricular force as dP/dt/EDV, which indicates the maximal rate of left ventricular pressure development divided by end-diastolic volume (EDV).

15. A method as claimed in claim 2, expressing the ventricular force as sP/ESV, which indicates the left ventricular end-systolic pressure volume ratio (end-systolic ventricular pressure divided by the end-systolic volume).