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Stabilization of implantable bioprosthetic devices

  • US 6,861,211 B2
  • Filed: 08/22/2001
  • Issued: 03/01/2005
  • Est. Priority Date: 04/27/1999
  • Status: Expired due to Term
First Claim
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1. A method of treating on implantable biological tissue, said method comprising stabilizing glycosaminoglycans on the tissue and cross-linking proteins on the tissue, wherein the glycosaminoglycans stabilizing comprises contacting the tissue with (a) a water-soluble carbodiimide composition having a pH of 6.9 to 7.9 or (b) a carbohydrate oxidizing agent and a bi-functional carbohydrate-protein linking agent, and the proteins cross-linking comprises contacting the tissue with a cross-linking reagent, wherein the cross linking reagent is a member selected from the group consisting of glutaraldehyde, formaldehyde, a dialdehyde, carbodiimide, and a polyepoxy ether.

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