Illumination device and method for spectroscopic analysis
First Claim
1. A spectroscopic system for measuring analyte concentration in a sample, the system comprising:
- a radiation source emitter, the emitter emitting radiation;
a radiation homogenizer disposed to receive at least a portion of said emitted radiation, wherein the homogenizer angularly and spatially homogenizes at least a portion of said emitted radiation, wherein said homogenized radiation illuminates said sample; and
a sample source, the sample source having an analyte; and
a detector for receiving at least a portion of the radiation subsequent to interacting with said sample.
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Accused Products
Abstract
An illumination subsystem for use in optical analysis which provides spatially and angularly homogenized radiation to the sample being analyzed. The system eliminates the illumination system as an interferent in the overall optical analysis. Thus, modest translations or rotations of the illumination source or changing the illumination source does not require recalibration of the instrument or prior modeling of illumination variability due to such changes. Illumination stability is achieved by incorporating a light pipe which both angularly and spatially homogenizes the light. Further, a series of filters and/or lenses are incorporated to provide bandpass filtering which eliminates unwanted wavelengths or bands of wavelengths from contacting the tissue and allows for a higher signal-to-noise ratio when the sample is tissue, while preventing thermal damage.
225 Citations
23 Claims
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1. A spectroscopic system for measuring analyte concentration in a sample, the system comprising:
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a radiation source emitter, the emitter emitting radiation;
a radiation homogenizer disposed to receive at least a portion of said emitted radiation, wherein the homogenizer angularly and spatially homogenizes at least a portion of said emitted radiation, wherein said homogenized radiation illuminates said sample; and
a sample source, the sample source having an analyte; and
a detector for receiving at least a portion of the radiation subsequent to interacting with said sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method for homogenizing radiation for spectroscopic analysis, the method comprising the steps of:
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providing a spectroscopic system, wherein the system comprises a radiation source emitter, a radiation homogenizer, a sample having an analyte concentration, and a radiation detector;
emitting radiation by means of the radiation source emitter;
angularly homogenizing the emitted radiation;
spatially homogenizing the emitted radiation;
illuminating the sample source with the homogenized radiation; and
detecting the analyte concentration within the sample source. - View Dependent Claims (19)
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20. An optical measurement system used to measure an analyte or attribute in a biological system, the system comprising:
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a spectrometer including a source and a collection system;
a sampling system for performing reflectance measurements on tissue;
a measurement system for measuring multiple wavelengths in the range for 4000 cm−
1 to 7500 cm−
1;
a prediction process that uses multiple variables obtained from the measurement system; and
an illumination system that does not introduce prediction errors of clinical significance when used in a standard manner. - View Dependent Claims (21, 22, 23)
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Specification