Multi-site cardiac stimulation device and method for detecting retrograde conduction

• US 6,862,477 B1
• Filed: 12/04/2002
• Issued: 03/01/2005
• Est. Priority Date: 06/13/2001
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Mo, Anthony
• Primary Examiner(s): MANUEL, GEORGE C
• Application Number:
  US10/310,429
• Time in Patent Office: 818 Days
• Field of Search: 607/9, 607/14, 607/17, 607/18, 607/25, 607/27, 600/515
• US Class Current: 607/27
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

An implantable cardiac stimulation device, such as a pacemaker, defibrillator and/or cardioverter, and an associated method that provide cardiac stimulation to at least two ventricular stimulation sites, within a single ventricle or across two ventricles. A high intrinsic atrial rate triggers a retrograde conduction detection routine when a high ventricular stimulation rate is sustained for a predetermined number of cycles during an atrial sensing mode. This routine interrupts concurrent stimulation, and alternates the stimulation output to the different ventricular sites.

Claims

1. In an implantable cardiac stimulation device, a method comprising:

delivering stimulation energy to at least two ventricular sites during at least some cardiac cycles;

detecting that a potential pacemaker-mediated tachycardia condition exists; and

alternating the delivery of stimulation energy to the at least two ventricular sites during subsequent cardiac cycles to terminate a retrograde conduction arising from one of the at least two ventricular sites.

2. The method of claim 1, further comprising determining average V-P intervals for the at least two ventricular sites, determining respective measures of variability for the respective V-P intervals, comparing the measures of variability with a threshold value, and determining that retrograde conduction exists for each ventricular site if the measures of variability fall below the threshold.

3. The method of claim 2, further comprising determining that no retrograde conduction exists if the measures of variability exceed the threshold.

4. The method of claim 2, wherein determining a measure of variability comprises determining a standard deviation for the V-P intervals corresponding to each ventricular site.

5. The method of claim 1, wherein alternating the delivery of stimulation energy comprises delivering stimulation energy to only one ventricular site per cardiac cycle.

6. The method of claim 2, wherein upon confirming retrograde conduction for the at least two ventricular sites, automatically adjusting an operating parameter.

7. The method of claim 6, wherein automatically adjusting an operating parameter comprises extending a post-ventricular atrial blanking period.

8. An implantable cardiac stimulation device comprising:

a sensor that is operative to detect cardiac activity;

a pulse generator that is operative to generate stimulation pulses to be delivered to at least two ventricular sites during normal cardiac cycles; and

a control circuit that is coupled to the sensor and that is operative to detect a potential pacemaker-mediated tachycardia condition based on the cardiac activity sensed by the sensor, wherein the control circuit is operative to control the pulse generator to alternate the stimulation of the at least two ventricular sites during subsequent cycles to terminate a retrograde conduction arising from one of the at least two ventricular sites.

9. The device of claim 8, wherein the control circuit is operative to determine average V-P intervals for the at least two ventricular sites, determine respective measures of variability for the respective V-P intervals, compare the measures of variability with a threshold value, and determine that retrograde conduction exists for each ventricular site if the measures of variability fall below the threshold.

10. The device of claim 9, wherein the control circuit is operative to determine that no retrograde conduction exists if the measures of variability exceed the threshold.

11. The device of claim 9, wherein the control circuit is operative to determine a standard deviation for the V-P intervals corresponding to each ventricular site.

12. The device of claim 8, wherein the control circuit is responsive to the potential pacemaker-mediated tachycardia condition to deliver stimulation energy to one ventricular site per cardiac cycle.

13. The device of claim 9, wherein the control circuit is responsive to detecting retrograde conduction for the at least two ventricular sites to automatically adjust an operating parameter.

14. The device of claim 13, wherein the operating parameter comprises a post-ventricular atrial blanking period.

15. An implantable cardiac stimulation device comprising:

means for delivering substantially concurrent ventricular stimulation pulses to at least two ventricular sites during at least some cardiac cycles;

means for detecting a potential retrograde conduction condition; and

means for alternating the stimulation of the two or more ventricular stimulation sites to terminate a retrograde conduction arising from one of the at least two ventricular sites.

16. The device of claim 15, further comprising means for determining average V-P intervals for the at least two ventricular sites, means for determining respective measures of variability for the respective V-P intervals, means for comparing the measures of variability with a threshold value, and means for detecting that retrograde conduction exists for each ventricular site if the measures of variability fall below the threshold.

17. The device of claim 16, further comprising means for determining that no retrograde conduction exists if the measures of variability exceed the threshold.

18. The device of claim 15, wherein the means for alternating comprises means for delivering stimulation energy to one ventricular site per cardiac cycle.

19. The device of claim 16, further comprising means for adjusting an operating parameter in response to the means for detecting retrograde conduction.

20. The device of claim 19, wherein the means for adjusting an operating parameter comprises means for adjusting a post-ventricular atrial blanking period.