Method and apparatus for computer modeling a joint

• US 6,862,561 B2
• Filed: 05/22/2002
• Issued: 03/01/2005
• Est. Priority Date: 05/29/2001
• Status: Expired due to Fees

• Current Assignee: Entelos Holding Corp. (SilkRoad Inc.)
• Original Assignee: Entelos, Inc. (SilkRoad Inc.)
• Inventors: Ramanujan, Saroja, Struemper, Herbert K., Paterson, Thomas S., Dubnicoff, Todd B., Lewis, Annette K., Shoda, Lisl K. M., Klinke, David J. II, Defranoux, Nadine A., Soderstrom, Karl Petter
• Primary Examiner(s): FREJD, RUSSELL WARREN
• Application Number:
  US10/154,123
• Publication Number:
  US 20030078759A1
• Time in Patent Office: 1,014 Days
• Field of Search: 703/22, 703/2, 703/6, 703/11, 607/1, 424/756, 382/128
• US Class Current: 703/11
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2002/30673 Lubricating means, e.g. synovial pocket
• CPC Class Codes: A61F 2002/30943 using mathematical models
• CPC Class Codes: A61F 2002/30952 using CAD-CAM techniques or NC-techniques
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

The present invention relates to a mathematical and computer model of a joint. The model includes representation of the biological processes related to the synovial tissue and cartilage. In one embodiment, the model represents a human joint afflicted with rheumatoid arthritis.

Claims

1. A method for developing a computer model of an animal joint, comprising:

identifying a plurality of biological processes related to the animal joint, the plurality of biological processes including at least one biological process related to cartilage metabolism; and

combining the plurality of biological processes to form a simulation of the animal joint.

2. The method of claim 1, wherein the animal joint is a human joint.

3. The method of claim 1, wherein the plurality of biological processes are related to a biological state of a normal joint.

4. The method of claim 1, wherein at least one biological process from the plurality of biological processes is associated with a biological variable that is a therapeutic agent.

5. The method of claim 1, further comprising:

selecting a therapeutic agent from at least one of methotrexate, steroids, non-steroidal anti-inflammatory drugs, soluble TNF-alpha receptor, TNF-alpha antibody, and interleukin-1 receptor antagonists; and

associating the selected therapeutic agent with at least one biological process from the plurality of biological processes.

6. The method of claim 1, wherein the plurality of biological processes are related to a biological state of a diseased joint.

7. The method of claim 6, wherein the biological state is the diseased joint afflicted with at least one of rheumatoid arthritis, osteoporosis, reactive arthritis and osteoarthritis.

8. The method of claim 6,

wherein identifying the plurality of biological processes includes identifying a set of biological processes related to changes in biological attributes of the diseased joint, and

wherein combining the plurality of biological processes includes combining the set of biological processes to form a simulation of at least one biological attribute of the diseased joint.

9. The method of claim 1, further comprising:

producing a simulated biological attribute associated with a biological state of the animal joint;

comparing the simulated biological attribute with a corresponding biological attribute associated with a reference pattern of the joint; and

identifying the computer model as a valid computer model of the animal joint if the simulated biological attribute is substantially consistent with the biological attribute associated with the reference pattern of the animal joint.

10. The method of claim 1, wherein combining the plurality of biological processes includes:

forming a first mathematical relation among biological variables associated with a first biological process from the plurality of biological processes; and

forming a second mathematical relation among biological variables associated with the first biological process and a second biological process from the plurality of biological processes.

11. The method of claim 10, further comprising:

creating a set of parametric changes in the first mathematical relation and the second mathematical relation; and

producing a simulated biological attribute based on at least one parametric change from the set of parametric changes, the simulated biological attribute being substantially consistent with at least one biological attribute associated with a reference pattern of the animal joint.

12. The method of claim 10, further comprising:

converting a first biological variable into a converted biological variable the value of which changes over time, the first biological variable being associated with at least one from the first mathematical relation and the second mathematical relation; and

producing a series of simulated biological attributes based on the converted biological variable, the series of simulated biological attributes being substantially consistent with a corresponding series of biological attribute associated with a reference pattern of the animal joint, the series of simulated biological attributes representing the chronological progression of a biological state of the animal joint.

13. The method of claim 10, further comprising:

converting a parameter into a converted biological variable the value of which changes over time, the parameter being associated with at least one from the first mathematical relation and the second mathematical relation; and

producing a series of simulated biological attributes based on the converted biological variable, the series of simulated biological attributes being substantially consistent with a corresponding series of biological attribute associated with a reference pattern of the animal joint, the series of simulated biological attributes representing the chronological progression of a biological state of the animal joint.

14. A processor-readable medium comprising code representing instructions to cause a processor to:

define a plurality of biological processes related to a biological state of an animal joint, the plurality of biological processes including at least one of a first set of biological processes related to tissue inflammation and a second set of biological processes related to cartilage metabolism; and

define a plurality of mathematical relationships related to interactions among biological variables associated with the plurality of biological processes, at least two biological processes from the plurality of biological processes being associated with the plurality of mathematical relationships, a combination of the plurality of biological processes and the plurality of mathematical relationships defining a simulation of the biological state of the animal joint.

15. The processor-readable medium of claim 14, wherein the first set of biological processes include at least one biological process related to synovial, tissue inflammation.

16. The processor-readable medium of claim 14, wherein at least one biological process from the plurality of biological processes is associated with a biological variable that is a therapeutic agent.

17. The processor-readable medium of claim 14, further comprising code representing instructions to cause the processor to:

select a therapeutic agent from at least one group of methotrexate, steroids, non-steroidal anti-inflammatory drugs, soluble TNF-alpha receptor, TNF-alpha antibody, and interleukin-1 receptor antagonists; and

associate the selected therapeutic agent with at least one biological process from the plurality of biological processes.

18. The processor-readable medium of claim 14, further comprising code representing instructions to cause the processor to:

define a first compartment, the first compartment including the first set of biological processes, and

define a second compartment, the second compartment including the second set of biological processes.

19. The processor-readable medium of claim 18, further comprising code representing instructions to cause the processor to:

define a third set of biological processes related to the interaction of the first compartment with the second compartment.

20. The processor-readable medium of claim 14, wherein the biological state is the state of a diseased joint.

21. The processor-readable medium of claim 20, wherein the biological state is the state is the state of a diseased joint afflicted with at least one of rheumatoid arthritis, osteoporosis, reactive arthritis or osteoarthritis, reactive arthritis, and osteoarthristis.

22. The processor-readable medium of claim 20, wherein upon execution of the code, a simulated biological attribute for the biological state of the diseased joint is produced, the simulated biological attribute being substantially consistent with at least one biological attribute associated with a reference pattern of the diseased joint.

23. A processor-readable medium comprising code representing instructions to cause a processor to:

define a plurality of compartments including a plurality of biological processes related to biological state of an animal joint, the plurality of compartments including at least one of;

a first compartment, the first compartment including a first set of biological processes related to synovial tissue

a second compartment, the second compartment including a second set of biological processes related to cartilage tissue,

the plurality of compartments defining a simulation of the biological state of the animal joint.

24. The processor-readable medium of claim 23, further comprising code representing instructions to cause the processor to:

define a first set of mathematical relations associated with the first set of biological processes and associated with interactions among biological variables associated with the first set of biological processes, and

define a set of mathematical relations associated with the second set of biological processes and associated with interactions among biological variables associated with the second set of biological processes.

25. The processor-readable medium of claim 23, further comprising code representing instructions to cause the processor to:

define a third set of biological processes related to the interaction of the first compartment with the second compartment.

26. A method for developing a computer model of a diseased joint, comprising:

receiving a plurality of user-selected indications to define a plurality of biological processes, each biological process from the plurality of biological processes being based on data that relates changes in biological states to biological attributes of the diseased joint, the plurality of biological processes including a set of biological processes related to at least one of tissue inflammation and tissue hyperplasia;

producing a simulated biological attribute associated with at least one biological attribute of the diseased joint based on the combined plurality of biology processes; and

assessing a validity of the computer model based on a comparison between the simulated biological attribute and a corresponding biological attribute associated with a reference pattern of the diseased joint.

27. The method of claim 26, wherein the diseased joint is afflicted with at least one of rheumatoid arthritis, osteoporosis, reactive arthritis and osteoarthritis.

28. The method of claim 26, wherein at least one biological process from the plurality of biological processes is associated with a biological variable that is a therapeutic agent.

29. The method of claim 26, further comprising:

selecting a therapeutic agent from at least one of methotrexate, steroids, non-steroidal anti-inflammatory drugs, soluble TNF-alpha receptor, TNF-alpha antibody, and interleukin-1 receptor antagonists; and

associating the selected therapeutic agent with at least one biological process from the plurality of biological processes.

30. A computer model of an animal joint, comprising:

a computer-readable memory storing;

code to define a pluriality of biological processes related to a biological state of the animal joint, at least one biological process from the plurality of biological processes being associated with a therapeutic agent; and

code to define a plurality of mathematical relationships related to interactions among biological variables associated with the plurality of biological processes, at least two biological processes from the plurality of biological processes being associated with the plurality of mathematical relationships, a combination of the code to define plurality of biological processes and the code to define the plurality of mathematical relationships defining a simulation of the biological state of the animal joint; and

a processor coupled to the computer-readable memory, the processor configured to execute the codes.

31. The computer model of claim 30, wherein the plurality of biological processes include a biological process related to at least one of cartilage metabolism, tissue inflammation, and tissue hyperplasia.

32. The computer model of claim 30, wherein the plurality of biological process include a biological process related to at least one of inflammatory mediators, proteases, fibroblast-like synoviocyte population, macrophage population, T lymphocyte population, B lymphocyte population, and dendritic cell population.

33. The computer model of claim 30, further comprising:

code to select the therapeutic agent from at least one of methotrexate, steroids, non-steroidal anti-inflammatory drugs, soluble TNF-alpha receptor, TNF-alpha antibody, and interleukin-1 receptor; and

antagonists; and

code to associate the selected therapeutic agent with at least one biological process from the plurality of biological processes.

34. The computer model of claim 30, wherein the plurality of biological processes include a first set of biological processes related to synovial tissue and a second set of biological processes related to cartilage tissue, the computer model further comprising:

code to define a first compartment, the first compartment including the first set of biological processes, and

code to define a second compartment, the second compartment including the second set of biological processes.

35. The computer model of claim 34, further comprising:

code to define a third set of biological processes related to the interaction of the first compartment with the second compartment.

36. The computer model of claim 30, wherein the biological state is the state of a diseased joint.

37. The computer model of claim 36, wherein the biological state is the state of the diseased joint afflicted with at least one of rheumatoid arthritis, osteoporosis, reactive arthritis and osteoarthritis.

38. The computer model of claim 36, wherein upon execution of the computer model, a simulated biological attribute for the biological state of the diseased joint is produced, the simulated biological attribute being substantially consistent with at least one biological attribute associated with a reference pattern of the diseased joint.

39. A method for developing an analytical model of an animal joint, comprising:

identifying a plurality of biological processes related to the animal joint, the plurality of biological processes including at least one biological process related to a set of inflammatory mediators; and

combining the plurality of biological processes to form an analytical representation of the animal joint.

40. The method of claim 39, wherein the plurality of biological processes are related to a biological state of a normal joint.

41. The method of claim 39, wherein the plurality of biological processes are related to a biological state of a diseased joint.

42. The method of claim 41, wherein the biological state is the state of the diseased joint afflicted with at least one of rheumatoid arthritis, osteoporosis, reactive arthritis, and osteoarthritis.

43. The method of claim 41, comprising:

wherein identifying the plurality of biological processes includes identifying a step of biological processes related to changes in biological attributes of the diseased joint, and

wherein combining the plurality of biological processes includes combining the set of biological processes to form an analytical representation of a least one biological attribute of the diseased joint.

44. The method of claim 39, further comprising:

producing an analytical representation of a biological attribute associated with a biological state of the animal joint;

producing an analytical representation of the biological attribute with a corresponding biological attribute associated with a reference pattern of the animal joint; and

identifying the analytical model as a valid model of the animal joint; and

identifying the analytical model as a valid model of the animal joint if the analytical representation of the biological attribute is substantially consistent with the biological attribute associated with the reference pattern of the animal joint.

45. The method of claim 39, wherein combining the plurality of biological processes includes:

forming a first mathematical relation among biological variables associated with a first biological process from the plurality of biological processes; and

forming a second mathematical relation among biological variables associated with the first biological process and a second biological process from the plurality of biological processes.

46. The method of claim 39, wherein the animal joint is a human joint.