Shear-enhanced systems and methods for removing waste materials and liquid from the blood

• US 6,863,821 B2
• Filed: 02/02/2002
• Issued: 03/08/2005
• Est. Priority Date: 02/02/2002
• Status: Active Grant

• Current Assignee: Baxter International Inc.
• Original Assignee: Baxter International Inc.
• Inventors: Moriarty, Julie, Vishnoi, Rohit, Kunas, Gretchen
• Primary Examiner(s): KIM, SUN U
• Application Number:
  US10/066,311
• Publication Number:
  US 20030146154A1
• Time in Patent Office: 1,130 Days
• Field of Search: 210/321.67, 210/321.68, 210/321.78, 210/360.1, 210/645, 210/646, 210/650, 210/780, 210/782
• US Class Current: 210/646
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/262 rotating
• CPC Class Codes: A61M 1/265 inducing Taylor vortices
• CPC Class Codes: A61M 1/3417 using distinct filters for dialysis and ultra-filtration
• CPC Class Codes: A61M 1/342 Adding solutions to the blood, e.g. substitution solutions for preventing coagulation A61M1/3672
• CPC Class Codes: A61M 1/3437 downstream of the filter, e.g. post-dilution with filtrate
• CPC Class Codes: A61M 1/3458 having electrolytes not present in the dialysate
• CPC Class Codes: B01D 2321/2033 dynamically
• CPC Class Codes: B01D 2321/2041 Mixers; Agitators
• CPC Class Codes: B01D 2321/205 Integrated pumps
• CPC Class Codes: B01D 61/145 Ultrafiltration
• CPC Class Codes: B01D 61/18 Apparatus therefor
• CPC Class Codes: B01D 61/28 Apparatus therefor
• CPC Class Codes: B01D 63/06 Tubular membrane modules
• CPC Class Codes: B01D 63/16 Rotary, reciprocated or vibrated modules
• CPC Class Codes: B01D 65/08 Prevention of membrane fouling or of concentration polarisation

Abstract

Systems and methods convey the blood through a gap defined between an inner surface that is located about an axis and an outer surface that is concentric with the inner surface. At least one of the inner and outer surfaces carries a membrane that consists essentially of either a hemofiltration membrane or a hemodialysis membrane. The systems and methods cause relative movement between the inner and outer surfaces about the axis at a selected surface velocity, taking into account the size of the gap. The relative movement of the two surfaces creates movement of the blood within the gap, which creates vortical flow conditions that induce transport of cellular blood components from the membrane while plasma water and waste material are transported to the membrane for transport across the membrane. Shear-enhanced transport of waste materials and blood plasma water results.

Claims

1. A system for removing waste from the blood of an individual comprising:

a blood processing device comprising a gap defined between an inner surface that is located about an axis and an outer surface that is concentric with the inner surface, an inlet and an outlet communicating with the gap, at least one of the inner and outer surfaces carrying a hemodialysis membrane, wherein the hemodialysis membrane includes a first surface facing toward the gap and a second surface,

the blood processing device including a channel to convey a dialysate along the second surface of the hemodialysis membrane to create a concentration gradient across the hemodialysis membrane to transport waste material from the blood,

a drive mechanism causing relative movement between the inner and outer surfaces about the axis at a selected surface velocity, and

a source of dialysate communicating with the channel.

2. A system according to claim 1

wherein the drive mechanism rotates the inner surface while holding the outer surface stationary.

3. A system according to claim 1

wherein the drive mechanism rotates the inner surface at a higher rate of rotation than the outer surface.

4. A system according to claim 1,

wherein the other of the inner and outer surfaces carries a hemofiltration membrane or a hemodialysis membrane.

5. A system according to claim 4

wherein the other surface carries a hemodialysis membrane.

6. A method for removing waste from the blood of an individual comprising the steps of conveying the blood through a gap defined between an inner surface that is located about an axis and an outer surface that is concentric with the inner surface, at least one of the inner and outer surfaces carrying a hemodialysis membrane,

causing relative movement between the inner and outer surfaces about the axis at a selected surface velocity, and

conveying a dialysate along an opposite side of the hemodialysis membrane to create a concentration gradient across the hemodialysis membrane to transport waste material from the blood.

7. A method according to claim 6

wherein the inner surface is rotated while holding the outer surface stationary.

8. A method according to claim 6

wherein the inner surface is rotated at a higher rate of rotation than the outer surface.

9. A method according to claim 6

wherein the other of the inner and outer surfaces carries a hemofiltration membrane or a hemodialysis membrane.

10. A method according to claim 9

wherein the other surface carries a hemodialysis membrane.