Human kinase and polynucleotides encoding the same

• US 6,864,079 B2
• Filed: 04/04/2002
• Issued: 03/08/2005
• Est. Priority Date: 04/06/2001
• Status: Expired due to Fees

• Current Assignee: Lexicon Genetics, Incorporated
• Original Assignee: Lexicon Genetics, Incorporated
• Inventors: Yu, Xuanchuan, Friddle, Carl Johan, Miranda, Maricar
• Primary Examiner(s): Monshipouri, Maryam
• Application Number:
  US10/116,332
• Publication Number:
  US 20020164737A1
• Time in Patent Office: 1,069 Days
• Field of Search: 435/194, 435/252.3, 435/325, 435/320.1, 435/6, 530/350, 536/23.2
• US Class Current: 435/194
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: C07H 21/04 with deoxyribosyl as saccharide radical
• CPC Class Codes: C07K 2319/02 containing a signal sequence
• CPC Class Codes: C12N 9/12 transferring phosphorus containing groups, e.g. kinases (2.7)

Abstract

Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.

Claims

1. An isolated nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:

1 or the complement thereof.

2. An isolated nucleic acid molecule comprising a nucleotide sequence encoding the amino acid sequence shown in SEQ ID NO:

2.

4. A recombinant expression vector comprising the isolated nucleic acid molecule of claim 2.

5. The recombinant expression vector of claim 4, wherein said vector comprises SEQ ID NO:

1.

6. A host cell comprises the recombinant expression vector of claim 4.

3. A substantially isolated protein having the kinase activity of the protein shown in SEQ ID NO:

2, which is encoded by a nucleotide sequence that hybridizes to entire SEQ ID NO;

1 under hybridization condition of 0.5 M NaHPO₄, 7% Sodium dodecyl sulfate (SDS), 1 mM EDTA at 65°

C., and wash conditions of 0.1×

SSC/0.1% SDS at 68°

C.