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Method of transplanting in a mammal and treating diabetes mellitus by administering a pseudo-islet like aggregate differentiated from a nestin-positive pancreatic stem cell

  • US 6,866,843 B2
  • Filed: 12/06/2000
  • Issued: 03/15/2005
  • Est. Priority Date: 12/06/1999
  • Status: Expired due to Term
First Claim
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1. A method of treating a patient with diabetes mellitus, comprising the steps of:

  • (a) isolating a nestin-positive pancreatic stem cell from a pancreatic islet of a donor;

    (b) expanding the stem cell to produce a progenitor cell;

    (c) differentiating the progenitor cell in culture to form pseudo-islet like aggregates; and

    (d) transferring the pseudo-islet like aggregates into the patient, wherein the patient does not serve as the donor for said stem cells of step (a), and wherein said transferring step (d) treats diabetes mellitus.

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