Prevention and treatment of amyloidogenic disease
First Claim
Patent Images
1. A method of therapeutically treating a disease characterized by an amyloid deposit of Aβ
- in a patient, comprising;
administering a dosage of an Aβ
peptide greater than 10 μ
g and an adjuvant in a regime effective to induce an immune response comprising antibodies to the Aβ
peptide, the adjuvant enhancing the immune response to the Aβ
peptide, and thereby therapeutically treat the disease in the patient.
7 Assignments
0 Petitions
Accused Products
Abstract
The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient. The methods are particularly useful for prophylactic therapeutic treatment of Alzheimer'"'"'s disease. In such methods, a suitable agent is Aβ peptide or an antibody thereto.
228 Citations
80 Claims
-
1. A method of therapeutically treating a disease characterized by an amyloid deposit of Aβ
- in a patient, comprising;
administering a dosage of an Aβ
peptide greater than 10 μ
g and an adjuvant in a regime effective to induce an immune response comprising antibodies to the Aβ
peptide, the adjuvant enhancing the immune response to the Aβ
peptide, and thereby therapeutically treat the disease in the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
- in a patient, comprising;
-
22. A method of prophylaxis of a disease characterized by an amyloid deposit of Aβ
- in a patient, comprising;
administering a dosage of an Aβ
peptide greater than 10 μ
g and an adjuvant in a regime effective to induce an immune response comprising antibodies to the Aβ
peptide, the adjuvant enhancing the immune response to the Aβ
peptide, and thereby effect prophylaxis of the disease in the patient. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42)
- in a patient, comprising;
-
43. A method of therapeutically treating a disease characterized by an amyloid deposit of Aβ
- in a patient, comprising;
administering an Aβ
peptide in a regime effective to induce an immune response comprising antibodies to the Aβ
peptide and thereby therapeutically treat the disease in the patient, wherein the dose of the Aβ
peptide administered to the patient is at least 50 μ
g. - View Dependent Claims (44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61)
- in a patient, comprising;
-
62. A method of prophylaxis of a disease characterized by an amyloid deposit of Aβ
- in a patient, comprising;
administering an Aβ
peptide in a regime effective to induce an immune response comprising antibodies to the Aβ
peptide and thereby effect prophylaxis of the disease in the patient, wherein the dose of the Aβ
peptide administered to the patient is at least 50 μ
g. - View Dependent Claims (63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80)
- in a patient, comprising;
Specification