Bi-laminar, hyaluronan coatings with silver-based anti-microbial properties
First Claim
Patent Images
1. An article including a surface having a bilaminar, lubricious, and hydrophilic coat thereon, said coating comprising:
- (a) a polysaccharide conponent; and
(b) an antibiotic ceramic component dispersed within the polysaccharide component, wherein the antibiotic ceramic component comprises a zeolite material.
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Abstract
An article including a surface having a coating thereon, in which the coating includes a base coat, firmly adhered to the surface, and a hydrophilic, biocompatible top-coat. An antibiotic ceramic component is dispersed in one or both of the base coat and top-coat. Preferably, the ceramic component is dispersed in the base coat. In a preferred embodiment, the ceramic component is a zeolite with silver ions exchanged onto internal acidic sites of the zeolite, and the top-coat includes a polysaccharide, such as hyaluronan. The zeolite is highly effective in imparting anti-microbial character to the coating.
94 Citations
20 Claims
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1. An article including a surface having a bilaminar, lubricious, and hydrophilic coat thereon, said coating comprising:
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(a) a polysaccharide conponent; and
(b) an antibiotic ceramic component dispersed within the polysaccharide component, wherein the antibiotic ceramic component comprises a zeolite material.
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2. An article including a surface having a bilaminar, lubricious, and hydrophilic coating thereon, said coating comprising:
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(a) a polysaccharide component; and
(b) an antibiotic ceramic component dispersed within the polysaccharide component, wherein the polysaccharide component comprises hyaluronan.
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3. An article including a surface having a bilaminar, lubricious, and hydrophilic coating thereon, said coating comprising:
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(a) a polysaccharide component; and
(b) an antibiotic ceramic component dispersed within the polysaccharide component, the article comprising a tubing made from a material selected from the group consisting of ethyl vinyl acetate and polyurethane.
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4. An article including a surface having a bilaminar, lubricious, and hydrophilic coating thereon, said coating comprising:
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(a) a polysaccharide component; and
(b) an antibiotic ceramic component dispersed within the polysaccharide component, wherein the surface is formed of a material selected from the group consisting of ethyl vinyl acetate and polyurethane.
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5. A method for providing an object with antibiotic properties for introduction of the object into an animal, said method comprising:
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coating the object on a surface portion thereof with bilaminar, lubricious, and hydrophilic coating comprising;
(i) a polysaccharide component; and
(ii) an antibiotic ceramic component dispersed within the polysaccharide component, wherein the polysaccharide component comprises hyaluronan.
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6. A method for providing an object with antibiotic properties for introduction of the object into an animal, said method comprising:
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coating the object on a surface portion thereof with bilaminar, lubricious, and hydrophilic coating comprising;
(i) a polysaccharide component; and
(ii) an antibiotic ceramic component dispersed within the polysaccharide component, wherein the object comprises a tubing made of a material selected from the group consisting of ethyl vinyl acetate and polyurethane.
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7. A method for providing an object with antibiotic properties for introduction of the object into an animal, said method comprising:
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coating the object on a surface portion thereof with a bilaminar, lubricious, and hydrophilic coating comprising;
(i) a polysaccharide component; and
(ii) an antibiotic ceramic component dispersed within the polysaccharide component, wherein the object comprises a material selected from the group consisting of ethyl vinyl acetate and polyurethane.
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8. An article comprising a coating, the coating being bilaminar, lubricious, and hydrophilic, the coating containing hyaluronan and a silver ion exchanged zeolite.
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9. An article comprising a substrate having a bilaminar coating, the coating including a base coat and a top-coat containing hyaluronan, wherein the base coat contains silver ion exchanged zeolite, and wherein the top coat is lubricious and hydrophilic.
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10. A method for providing an object with antibiotic properties for introduction of the object into an animal, said method comprising:
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coating the object on a surface portion thereof with a bilaminar, lubricious, and hydrophilic coating comprising;
(i) a base coat which adheres firmly to said surface portion, and (ii) a hydrophilic, biocompatible top-coat, the top-coat being chemically grafted to said base coat, the top-coat including a polysaccharide component, the method further comprising dispersing an antibiotic ceramic component within said base coat. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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19. An article having a bilaminar, lubricious, and hydrophilic coating which includes a polysaccharide and silver ion exchanged zeolite.
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20. An article having a bilaminar, lubricious, and hydrophilic coating which includes hyaluronan and a silver ion exchanged zeolite.
Specification