Human hydroxylases and polynucleotides encoding the same

• US 6,867,025 B2
• Filed: 05/23/2002
• Issued: 03/15/2005
• Est. Priority Date: 05/29/2001
• Status: Expired due to Term

• Current Assignee: Lexicon Pharmaceuticals, Inc. (The Invus Group LLC)
• Original Assignee: Lexicon Genetics, Incorporated
• Inventors: Hu, Yi, Yu, Xuanchuan, Miranda, Maricar
• Primary Examiner(s): Patterson, Jr., Charles L.
• Application Number:
  US10/154,674
• Publication Number:
  US 20020192694A1
• Time in Patent Office: 1,027 Days
• Field of Search: 435/189, 536/23.2
• US Class Current: 435/189
• CPC Class Codes: A01K 2217/05 Animals comprising random inserted nucleic acids (transgenic)
• CPC Class Codes: C07K 2319/00 Fusion polypeptide
• CPC Class Codes: C12N 9/0004 Oxidoreductases (1.)

Abstract

Novel human polynucleotide and polypeptide sequences are disclosed that can be used in industrial, therapeutic, diagnostic, and pharmacogenomic applications.

Claims

1. An isolated nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:

7.

2. The isolated nucleic acid molecule of claim 1, wherein the molecule comprises the nucleotide sequence of SEQ ID NO:

5.

3. The isolated nucleic acid molecule of claim 2, wherein the molecule comprises the nucleotide sequence of SEQ ID NO:

3.

4. The isolated nucleic acid molecule of claim 3, wherein the molecule comprises the nucleotide sequence of SEQ ID NO:

1.

5. An isolated nucleic acid molecule comprising a nucleotide sequence that:

(a) encodes the amino acid sequence shown in SEQ ID NO;

4; and

(b) hybridizes under highly stringent conditions to the nucleotide sequence of SEQ ID NO;

3 or the complement thereof.

6. An isolated nucleic acid molecule encoding the amino acid sequence described in SEQ ID NO:

8.

7. The isolated nucleic acid molecule of claim 6, wherein the molecule encodes the amino acid sequence of SEQ ID NO:

6.

8. The isolated nucleic acid molecule of claim 7, wherein the molecule encodes the amino acid sequence of SEQ ID NO:

4.

9. The isolated nucleic acid molecule of claim 8, wherein the molecule encodes the amino acid sequence of SEQ ID NO:

2.

10. A substantially isolated protein having the activity of the protein shown in SEQ ID NOS:

2, 4, 6, or 8, which is encoded by a nucleotide sequence that hybridizes to SEQ ID NO;

1, 3, 5, or 7 under highly stringent conditions.

11. The substantially isolated protein of claim 10, wherein said protein comprises he amino acid sequence of SEQ ID NO:

8.

12. The substantially isolated protein of claim 10, wherein said protein comprises he amino acid sequence of SEQ ID NO:

6.

13. The substantially isolated protein of claim 10, wherein said protein comprises he amino acid sequence of SEQ ID NO:

4.

14. The substantially isolated protein of claim 10, wherein said protein comprises he amino acid sequence of SEQ ID NO:

2.