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Simultaneous stimulation and concentration of cells

  • US 6,867,041 B2
  • Filed: 04/26/2002
  • Issued: 03/15/2005
  • Est. Priority Date: 02/24/2000
  • Status: Expired due to Term
First Claim
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1. A method for stimulating a population of T-cells by cell surface moiety ligation, comprising:

  • (i) providing a population of cells wherein at least a portion thereof comprises T-cells;

    (ii) contacting said population of cells with a surface, wherein said surface has attached thereto a first agent that ligates a TCR/CD3 complex of a T-cell, and the same or a second surface has attached thereto a second agent that ligates a CD28 accessory molecule of said T-cell, wherein the ratio of said first agent to said second agent is less than one and wherein said ligation by the first and second agent induces proliferation of said T-cell.

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