Multiplexed active biologic array
First Claim
1. A method of addressing and driving a biologic electrode array comprising the steps of:
- providing a chip having an array of electrodes, each electrode being associated with a local memory;
addressing one or more electrodes within the array using a plurality of row and column lines, wherein each addressable electrode is connectable to a single row line and a single column line;
storing a value in the local memory of each addressed electrode representative of a voltage that is to be applied to each addressed electrode; and
driving the addressed electrodes at the voltage corresponding to the stored values.
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Accused Products
Abstract
A method of addressing and driving an electrode array includes the step of addressing one or more electrodes within the array using a plurality of row and column lines. In one aspect of the method, a value corresponding to a voltage is stored in a local memory associated with each electrode. The addressed electrodes are then driven at the voltages corresponding to the stored values. In another aspect of the method, a driving element associated with each addressed electrode is selectively coupled with a voltage line so as to charge the electrode with the voltage on the voltage line. The device and methods may be used in the synthesis of biopolymers such as oligonucleotides and peptides.
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Citations
28 Claims
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1. A method of addressing and driving a biologic electrode array comprising the steps of:
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providing a chip having an array of electrodes, each electrode being associated with a local memory;
addressing one or more electrodes within the array using a plurality of row and column lines, wherein each addressable electrode is connectable to a single row line and a single column line;
storing a value in the local memory of each addressed electrode representative of a voltage that is to be applied to each addressed electrode; and
driving the addressed electrodes at the voltage corresponding to the stored values. - View Dependent Claims (2, 3, 4)
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5. A method of addressing and driving a biologic electrode array comprising the steps of:
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providing a chip having an array of electrodes, each electrode being associated with a driving element;
addressing one or more electrodes within the array using a plurality of row and column lines, wherein each addressable electrode is connectable to a single row line and a single column line;
selectively coupling the driving element of the one or more addressed electrodes with a voltage line so as to charge the addressed electrode with the voltage on the voltage line. - View Dependent Claims (6)
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7. A method of carrying out biological reactions on a biologic electrode array comprising the steps of:
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providing a chip having an array of electrodes, each electrode being associated with a local memory;
providing a reaction medium including reactants within close proximity of the array of electrodes;
addressing one or more electrodes within the array using a plurality of row and column lines, wherein each addressable electrode is connectable to a single row line and a single column line;
storing a value in the local memory of each addressed electrode representative of a voltage that is to be applied to each addressed electrode; and
driving the one or more addressed electrodes at the voltage corresponding to the stored values, whereby the electrical field created at the one or more electrodes is used to react the reactants contained in the reaction medium at a location adjacent to the electrode. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14)
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15. A method of carrying out biological reactions on a biologic electrode array comprising the steps of:
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providing a chip having an array of electrodes, each electrode being associated with a driving element;
providing a reaction medium including reactants within close proximity of the array of electrodes;
addressing one or more electrodes within the array using a plurality of row and column lines, wherein each addressable electrode is connectable to a single row line and a single column line; and
selectively coupling the driving element of the one or more addressed electrodes with a voltage line so as to charge the addressed electrode with the voltage on the voltage line, whereby the electrical field created at the one or more electrodes is used to react the reactants contained in the reaction medium at a location adjacent to the electrode. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22)
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23. An biologic electrode array comprising:
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a semiconductor substrate;
a matrix of electrode sites disposed on the semiconductor substrate;
a local memory coupled to each electrode site;
row and column decoders for addressing the electrode sites using a plurality of row and column lines;
a data line for delivering to the local memory a value indicative of a characteristic of an electrical stimulus to be applied at the electrode site; and
a driving element located at each electrode site, the driving element delivering the electrical stimulus to each electrode site in response to the stored value in the local memory. - View Dependent Claims (24, 25, 26, 27, 28)
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Specification