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Use of adipsin/complement factor D in the treatment of metabolic related disorders

  • US 6,867,189 B2
  • Filed: 07/22/2002
  • Issued: 03/15/2005
  • Est. Priority Date: 07/26/2001
  • Status: Expired due to Fees
First Claim
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1. A method of reducing body mass in an individual comprising administering to said individual a composition comprising a carrier and an Adipsin polypeptide comprising:

  • a) amino acids 21-253 or 26-253 of SEQ ID NO;

    2 and i) the amino acid at position 26 is Met;

    ii) the amino acid at position 52 is Gly;

    iii) the amino acid at position 59 is Gln;

    or iv) the amino acid at position 150 is Leu;

    or b) amino acids 20-253 or 26-253 of SEQ ID NO;

    4 and i) the amino acid at position 26 is Met;

    ii) the amino acid at position 52 is Gly;

    iii) the amino acid at position 59 is Gln;

    or iv) the amino acid at position 150 is Leu;

    said composition further optionally comprising Apm1 (Adipose Most Abundant Gene Transcript

         1) polypeptide.

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