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Modified polynucleotides and uses thereof

  • US 6,867,290 B2
  • Filed: 10/26/2001
  • Issued: 03/15/2005
  • Est. Priority Date: 04/30/1999
  • Status: Expired due to Fees
First Claim
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1. A method for producing a composition comprising a modified poly-ribonucleotide, wherein said modified poly-ribonucleotide is an mRNA, rRNA, or viral RNA, said method comprising the steps of:

  • (i) contacting a poly-ribonucleotide in a reaction medium comprising at least 80% v/v organic solvent with a reactant capable of covalently modifying the 2′

    -OH position of the ribose rings of said poly-ribonucleotide; and

    (ii) reacting said poly-ribonucleotide to produce a modified poly-ribonucleotide comprising greater than 25% of ribose rings bearing a C1-C10 alkanoyl at their 2′

    -OH position.

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