Method and device for intravascular plasma fluid removal
First Claim
1. An intravascular device for removing plasma fluid from a patient'"'"'s blood, said device comprising (a) a dual lumen intravascular catheter having open and closed ends wherein the lumina are coaxially disposed as a central core channel and a circumferential outer channel within said catheter, said channel containing the inner lumen, said inner lumen having near and distal ends and being open at both the near end and distal end of the device;
- (b) inlet and outlet tubing ports at the near open end of the inner lumen and the open end of the outer lumen respectively, said inlet port communicating with the inner lumen configured to allow a fresh hyperosmotic fluid to pass into the inner lumen and out through the distal open end of the core channel and then flow back through the circumferential outer lumen and out of the device through the outlet tubing port, which communicates with the outer lumen;
(c) the outer lumen being defined by the circumferential channel of the coaxial configuration and formed between the core channel and the inner surface of the outer catheter wall comprising a semipermeable membrane and having its outer surface so positioned to directly contact whole blood passing by it;
(d) said inner lumen being formed from a nonpermeable polymer, so arranged as to permit a continuous supply of fresh hyperosmotic fluid to the outer lumen and thereby exert sufficient osmotic pressure to force plasma fluid from the blood, crossing from the outer to inner surfaces of the circumferential semipermeable wall, into said outer lumen and thence out the outflow port, said device further comprising luer locks disposed at each of the ends of the inlet and outlet ports, and wherein the luer lock disposed at the end of the outlet port further comprises a guide wire having a hub at one end thereof, said hub being removably secured to said luer lock.
0 Assignments
0 Petitions
Accused Products
Abstract
Plasma fluid removal is needed in a variety of clinical conditions including congestive heart failure and moderate renal insufficiency. In order to avoid the problems inherent in extracorporeal ultrafiltration methods, the present invention removes fluid using an intravascular or intracorporeal dual-lumen catheter. Plasma fluid is driven across a semipermeable membrane, as in an in vivo vascular catheter. Suboptimal intracatheter flow, luminal collapse, erratic high transmembrane flow with nonhomogenous caking and clotting of the external catheter surface are all avoided by inducing pressure gradients across the wall by means of osmotic forces instead of negative pressures induced by hydraulic pumps. Osmotically induced fluid flow would tend to keep the lumena slightly distended and thereby simplify the fluid delivery systems. Osmotic gradients are maintained by utilizing dual lumen catheters typically placed in large central veins, and attached to pumps supplying high osmolality sterile solutions (such as dextrose or other sugars). Such a sealed system using readily available sterile sugar solutions and biocompatible catheter substrate would be extremely safe.
-
Citations
28 Claims
-
1. An intravascular device for removing plasma fluid from a patient'"'"'s blood, said device comprising (a) a dual lumen intravascular catheter having open and closed ends wherein the lumina are coaxially disposed as a central core channel and a circumferential outer channel within said catheter, said channel containing the inner lumen, said inner lumen having near and distal ends and being open at both the near end and distal end of the device;
- (b) inlet and outlet tubing ports at the near open end of the inner lumen and the open end of the outer lumen respectively, said inlet port communicating with the inner lumen configured to allow a fresh hyperosmotic fluid to pass into the inner lumen and out through the distal open end of the core channel and then flow back through the circumferential outer lumen and out of the device through the outlet tubing port, which communicates with the outer lumen;
(c) the outer lumen being defined by the circumferential channel of the coaxial configuration and formed between the core channel and the inner surface of the outer catheter wall comprising a semipermeable membrane and having its outer surface so positioned to directly contact whole blood passing by it;
(d) said inner lumen being formed from a nonpermeable polymer, so arranged as to permit a continuous supply of fresh hyperosmotic fluid to the outer lumen and thereby exert sufficient osmotic pressure to force plasma fluid from the blood, crossing from the outer to inner surfaces of the circumferential semipermeable wall, into said outer lumen and thence out the outflow port, said device further comprising luer locks disposed at each of the ends of the inlet and outlet ports, and wherein the luer lock disposed at the end of the outlet port further comprises a guide wire having a hub at one end thereof, said hub being removably secured to said luer lock. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
- (b) inlet and outlet tubing ports at the near open end of the inner lumen and the open end of the outer lumen respectively, said inlet port communicating with the inner lumen configured to allow a fresh hyperosmotic fluid to pass into the inner lumen and out through the distal open end of the core channel and then flow back through the circumferential outer lumen and out of the device through the outlet tubing port, which communicates with the outer lumen;
-
19. An intravascular device for removing plasma fluid from a patient'"'"'s blood, said device comprising (a) a dual lumen intravascular catheter having an outer wall, said outer wall being semipermeable and further having open and closed ends wherein the lumina are disposed in a side-by-side configuration with an inflow channel and an outflow channel within said catheter said inflow and outflow channels being separated by a nonpermeable septum, said inflow channel having open ends at both the near end and distal ends of the device;
- (b) inlet and outlet tubing ports at the near open end of the inflow channel and the open end of the outflow channel respectively, said inlet port communicating with the inflow channel for enabling a fresh hyperosmotic fluid to pass into the inflow channel and out through the distal open end of the inflow channel and then flow back through the outflow channel and out of the device through the outlet tubing port, which communicates with the outflow channel;
(c) the outflow channel being defined and formed by a surface on the outer catheter wall comprising to directly contact whole blood passing by it;
(d) said inflow channel being formed from a nonpermeable polymer, so arranged as to permit a continuous supply of fresh hyperosmotic fluid to the outflow channel and thereby exert sufficient osmotic pressure to force plasma fluid from the blood, crossing from the outflow channel into said outflow channel and thence out the outflow port;
said device further comprising luer locks disposed at each of the ends of the inlet and outlet ports, and wherein the luer lock disposed at the end of the outlet port further comprises a guide wire having a hub at one end thereof, said hub being removably secured to said luer lock, said device further comprising luer locks disposed at each of the ends of the outlet ports, and wherein the luer lock disposed at the end of the outlet port further comprises a guide wire having a hub at one end thereof, said hub being removably secured to said luer lock. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28)
- (b) inlet and outlet tubing ports at the near open end of the inflow channel and the open end of the outflow channel respectively, said inlet port communicating with the inflow channel for enabling a fresh hyperosmotic fluid to pass into the inflow channel and out through the distal open end of the inflow channel and then flow back through the outflow channel and out of the device through the outlet tubing port, which communicates with the outflow channel;
Specification