Method and apparatus for patient temperature control employing administration of anti-shivering agents

• US 6,869,440 B2
• Filed: 08/09/2002
• Issued: 03/22/2005
• Est. Priority Date: 02/09/1999
• Status: Expired due to Term

• Current Assignee: Zoll Circulation Incorporated (Asahi Kasei Corporation)
• Original Assignee: Innercool therapies Incorporated (Taxus Cardium Pharmaceuticals Group, Inc.)
• Inventors: Dobak, John D. III
• Primary Examiner(s): GIBSON, ROY DEAN
• Application Number:
  US10/216,405
• Publication Number:
  US 20030060863A1
• Time in Patent Office: 956 Days
• Field of Search: 607104-106
• US Class Current: 607/105
• CPC Class Codes: A61F 2007/0056 for cooling
• CPC Class Codes: A61F 2007/0288 during operations
• CPC Class Codes: A61F 2007/126 for invasive application, e.g. for introducing into blood vessels
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities
• CPC Class Codes: A61F 7/123 using a flexible balloon containing the thermal element
• CPC Class Codes: A61M 2025/0004 having two or more concentrically arranged tubes for forming a concentric catheter system
• CPC Class Codes: A61M 2025/006 having a special surface topography or special surface properties, e.g. roughened or knurled surface
• CPC Class Codes: A61M 2205/3606 cooled
• CPC Class Codes: A61M 25/00 Catheters; Hollow probes dilators A61M29/00; peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00 ; for measuring or testing A61B; materials for catheters A61L29/00
• CPC Class Codes: A61M 25/0023 by the form of the lumen, e.g. cross-section, variable diameter

Abstract

Embodiments of the invention provide a system for temperature control of the human body. The system includes an indwelling catheter with a tip-mounted heat transfer element. The catheter is fluidically coupled to a console that provides a heated or cooled heat transfer working fluid to exchange heat with the heat transfer element, thereby heating or cooling blood. The heated or cooled blood then heats or cools the patient'"'"'s body or a selected portion thereof. In particular, strategies for providing cooling while reducing shivering are disclosed, including administration of various drugs and drug combinations.

Claims

1. A method of changing the temperature of a human body, comprising:

inserting a catheter having a heat transfer element into a vein of a patient;

circulating a working fluid through the catheter and the heat transfer element, the working fluid having a temperature different from the patient temperature;

administering a therapeutic amount of meperidine, whereby shivering is lessened.

2. The method of claim 1, further comprising circulating a working fluid through the catheter and the heat transfer element, the working fluid having a temperature higher than the patient temperature.

3. The method of claim 1, further comprising circulating a working fluid through the catheter and the heat transfer element, the working fluid having a temperature lower than the patient temperature.

4. A method of changing the temperature of a human body, comprising:

inserting a catheter having a heat transfer element into a vein of a patient;

circulating a working fluid through the catheter and the heat transfer element, the working fluid having a temperature different from the patient temperature;

administering a therapeutic amount of a prodine, whereby shivering is lessened.

5. The method of claim 4, further comprising circulating a working fluid through the catheter and the heat transfer element, the working fluid having a temperature higher than the patient temperature.

6. The method of claim 4, further comprising circulating a working fluid through the catheter and the heat transfer element, the working fluid having a temperature lower than the patient temperature.

7. A method of changing the temperature of a human body, comprising:

inserting a catheter having a heat transfer element into a vein of a patient;

circulating a working fluid through the catheter and the heat transfer element, the working fluid having a temperature different from the patient temperature;

administering a therapeutic amount of fentanyl, whereby shivering is lessened.

8. The method of claim 7, further comprising circulating a working fluid through the catheter and the heat transfer element, the working fluid having a temperature higher than the patient temperature.

9. The method of claim 7, further comprising circulating a working fluid through the catheter and the heat transfer element, the working fluid having a temperature lower than the patient temperature.

10. A method of changing the temperature of a human body, comprising:

inserting a catheter having a heat transfer element into a vein of a patient;

circulating a working fluid through the catheter and the heat transfer element, the working fluid having a temperature different from the patient temperature;

administering a therapeutic amount of a drug selected from the group consisting essentially of prodine, fentanyl, and an opioid, in combination with a delta opiate receptor antagonist, whereby shivering is lessened.

11. The method of claim 10, further comprising circulating a working fluid through the catheter and the heat transfer element, the working fluid having a temperature higher than the patient temperature.

12. The method of claim 10, further comprising circulating a working fluid through the catheter and the heat transfer element, the working fluid having temperature lower than the patient temperature.

13. The method of claim 10, wherein the antagonist is naltrindole or naltriben.

14. A method of changing the temperature of a human body, comprising:

inserting a catheter having a heat transfer element into a vein of a patient;

circulating a working fluid through the catheter and the heat transfer element, the working fluid having a temperature different from the patient temperature;

administering a therapeutic amount of a (+) isomer of a prodine in which a hydroxyl has been added to the phenyl ring, whereby shivering is lessened.

15. The method of claim 14, wherein the hydroxyl is added in the m position.

16. The method of claim 14, wherein the prodine is alpha-allylprodine, and the 3-methyl is replaced with an allyl group.

17. A method of changing the temperature of a human body, comprising:

inserting a catheter having a heat transfer element into a vein of a patient;

circulating a working fluid through the catheter and the heat transfer element, the working fluid having a temperature different from the patient temperature;

administering a therapeutic amount of a (+) beta isomer of a prodine in which the 3-methyl group is replaced with an n-propyl or allyl group, whereby shivering is lessened.

18. A method of changing the temperature of a human body, comprising:

inserting a catheter having a heat transfer element into a vein of a patient;

circulating a working fluid through the catheter and the heat transfer element, the working fluid having a temperature different from the patient temperature;

administering a therapeutic amount of a isomer of a cis-picenadol.

19. The method of claim 18, wherein the isomer is the (−

) enantiomer.

20. The method of claim 18, further comprising administering a therapeutic amount of a racemic mixture of isomers of a cis-picenadol.

21. A method of changing the temperature of a human body, comprising:

inserting a catheter having a heat transfer element into a vein of a patient;

circulating a working fluid through the catheter and the heat transfer element, the working fluid having a temperature different from the patient temperature;

administering a therapeutic amount of a isomer of tramadol.

22. A method of changing the temperature of a human body, comprising:

inserting a catheter having a heat transfer element into a vein of a patient;

circulating a working fluid through the catheter and the heat transfer element, the working fluid having a temperature different from the patient temperature;

administering a therapeutic amount of a isomer a nefopam.

23. The method of claim 22, wherein the isomer is the (−

) enantiomer.

24. The method of claim 22, further comprising administering a therapeutic amount of a drug selected from the group consisting essentially of a prodine, meperidine, thorazine, buspirone, clonidine, and tramadol, and combinations thereof.