Apparatus for analyzing biologic fluids

• US 6,869,570 B2
• Filed: 12/14/2001
• Issued: 03/22/2005
• Est. Priority Date: 03/07/1998
• Status: Expired due to Term

• Current Assignee: Abbott Laboratories, Robert A. Levine, Wardlaw Partners LP
• Original Assignee: Robert A. Levine, Wardlaw Partners LP
• Inventors: Wardlaw, Stephen C.
• Primary Examiner(s): Warden, Jill
• Assistant Examiner(s): SINES, BRIAN J
• Application Number:
  US10/023,405
• Publication Number:
  US 20020055178A1
• Time in Patent Office: 1,194 Days
• Field of Search: 422/50, 422/55, 422/58, 422/68.1, 422/73, 422/82.05, 422/52, 422/82.06, 422/82.07, 422/82.08, 422/82.09, 422/82.11, 422/100, 422/102, 422/104, 436/63, 436/66, 436/69, 436/70, 436/164, 436/165, 436/169, 436/172, 356/244, 356/246
• US Class Current: 422/82.05
• CPC Class Codes: G01N 15/05 in blood
• CPC Class Codes: G01N 15/1433 using image recognition
• CPC Class Codes: G01N 2015/014 Reticulocytes
• CPC Class Codes: G01N 2015/016 White blood cells
• CPC Class Codes: G01N 2015/018 Platelets
• CPC Class Codes: G01N 2015/055 for hematocrite determination
• CPC Class Codes: G01N 2015/145 by pattern of light, e.g. fringe pattern
• CPC Class Codes: G01N 2015/1486 Counting the particles
• CPC Class Codes: G01N 2015/1497 Particle shape
• CPC Class Codes: G01N 33/5002 Partitioning blood components

Abstract

An apparatus and method for analyzing a sample of biologic fluid quiescently residing within a chamber is provided. The apparatus includes a light source, a positioner, a mechanism for determining the volume of a sample field, and an image dissector. The light source is operable to illuminate a sample field of known, or ascertainable, area. The positioner is operable to selectively change the position of any or any or all of the chamber, the light source, or the image dissector, thereby enabling selective illumination of all regions of the sample. The mechanism for determining the volume of a sample field can determine the volume of a sample field illuminated by the light source. The image dissector is operable to convert an image of light passing through or emanating from the sample field into an electronic data format.

Claims

1. An apparatus for testing a sample of biologic fluid quiescently residing within a chamber, said apparatus comprising:

a field illuminator for selectively illuminating a field of the sample, said field having a known or ascertainable area;

an image dissector for convening an image of light passing through or emanating from the field of the sample into an electronic data format useful for test purposes;

a positioner operable to selectively change the relative position of any or all of the chamber, the field illuminator, or the image dissector, thereby enabling selective illumination of a plurality of the sample fields within the chamber; and

means for determining one of a through-plane thickness or a volume of each sample field.

2. The apparatus of claim 1 further comprising means for spatially locating the relative positions of any or all of the chamber, the field illuminator, or the image dissector, to enable selective imaging of any particular spatial location within the chamber.

3. An apparatus for testing a sample of biologic fluid, said apparatus comprising:

a container that includes a chamber for quiescently holding the sample during the test;

a field illuminator for illuminating a portion or all of the chamber;

an image dissector for converting an image of light passing through or emanating from the sample into an electronic data format useful for test purposes; and

means for determining one of a through-plane thickness or a volume of each sample field.