Composition and method of effecting superficial chemical skin peels

• US 6,869,611 B1
• Filed: 08/07/1998
• Issued: 03/22/2005
• Est. Priority Date: 02/08/1996
• Status: Expired due to Fees

• Current Assignee: Albert M. Kligman, Douglas E. Kligman
• Original Assignee: Albert M. Kligman, Douglas E. Kligman
• Inventors: Kligman, Albert M., Kligman, Douglas E.
• Primary Examiner(s): Kishore, Gollamudi S.
• Assistant Examiner(s): TRAN, SUSAN T
• Application Number:
  US09/131,076
• Time in Patent Office: 2,419 Days
• Field of Search: 424/59, 424/60, 424/401, 514/887
• US Class Current: 424/401
• CPC Class Codes: A61K 2800/28 Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
• CPC Class Codes: A61K 31/60 Salicylic acid; Derivatives thereof
• CPC Class Codes: A61K 8/368 with carboxyl groups directly bound to carbon atoms of aromatic rings
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/004 Aftersun preparations
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

A method for effecting a superficial chemical skin peel is provided wherein a concentrated solution of salicylic acid in a dermatologically acceptable solvent is applied to be treated. The concentrated salicylic acid solution contains at least 15 wt % salicylic acid and preferably at least about 20 wt % salicylic acid, The composition and method are useful in the treatment of skin disorders such as photodamaged skin, hyperpigmentation, acne vulgaris, and the like.

Claims

1. A method for effecting a superficial chemical skin peel which comprises topically applying to skin to be treated a solution of salicylic acid containing at least 15 wt % up to a saturation concentration of salicylic acid, based on the weight of the solution, in a dernatologically acceptable, volatile, liquid solvent, allowing the salicylic acid to be present as a solution on a surface of the skin for a time sufficient to produce a chemical peel of stratum corneum of the skin with viable epidermis remaining substantially intact, allowing the applied solution to dry on the skin, and wiping the treated skin after the applied solution has dried, to remove residue from the applied solution from the skin.

2. The method of claim 1 wherein the salicylic acid is present in the solution in an amount of at least about 20 wt %.

3. The method of claim 1 wherein the salicylic acid is present in the solution in an amount of at least about 30 wt %.

4. The method of claim 1 wherein the solvent is selected from the group consisting of ethanol, isopropanol, methanol, acetone and diethyl ether.

5. The method of claim 1 wherein the solution comprises salicylic acid in ethanol.

6. The method of claim 1 wherein the treated skin is wiped with water.

7. The method of claim 1 wherein the step of wiping the treated skin occurs no later than one hour after the solution has been applied, to remove residual applied solution.

8. The method of claim 7 wherein the treated skin is wiped with water.

9. The method of claim 1 wherein the treated skin is facial skin.

10. The method of claim 1 wherein the skin being treated is affected with a skin disorder selected from the group consisting of photodamaged skin, hyperpigmentation, acne vulgaris, rosacea, premalignant skin cancer, wrinkles and superficial scarring.

11. The method of claim 10 wherein the skin disorder is hyperpigmentation.

12. The method of claim 10 wherein the skin disorder is acne vulgaris, selected from inflammatory acne, comedonal acne and acne-induced scarring.