Dual pad liquid shear valve assembly

• US 6,872,361 B2
• Filed: 06/28/2001
• Issued: 03/29/2005
• Est. Priority Date: 06/28/2001
• Status: Active Grant

• Current Assignee: Coulter International Corp.
• Original Assignee: Coulter International Corp.
• Inventors: Minnich, Helen A., Li, William Weigong
• Primary Examiner(s): Ludlow, Jan M.
• Application Number:
  US09/894,795
• Publication Number:
  US 20030026741A1
• Time in Patent Office: 1,370 Days
• Field of Search: 422/103, 738/637.3, 251/149, 251/149.1, 251/142, 251/143, 251/153
• US Class Current: 422/540
• CPC Class Codes: F16K 11/0655 with flat slides
• CPC Class Codes: G01F 11/16 for liquid or semiliquid
• CPC Class Codes: G01N 35/1097 characterised by the valves valves in general F16K

Abstract

A shear valve assembly comprises a pair of valve pads having opposing planar surfaces supported for relative sliding engagement. Each valve pad defines a plurality of liquid pathways by which a liquid can be passed from one pad to the other. The planar surface of one of the valve pads has an open channel formed therein, such channel having dimensions to accommodate a prescribed volume of liquid. Liquid is introduced into such channel via a first pair of pathways formed in the other valve pad, and liquid is dispensed from the open channel by a second pair of pathways that are brought into alignment with the channel during sliding movement between the valve pads. The valve assembly is particularly useful in blood-analyzing instruments for isolating and dispensing relatively minute volumes (of the order of microliters) of whole blood for analysis.

Claims

1. A dual-pad liquid shear valve assembly for isolating a first, relatively small prescribed volume of sample liquid from a larger volume of sample liquid presented to said valve assembly from a source of sample liquid and for positioning said prescribed volume of sample liquid for subsequent dispensing together with a diluent adapted to dilute said sample liquid, said valve assembly comprising:

a first valve pad having a first planar surface and containing a first plurality of liquid pathways therethrough which intersect said first planar surface;

a second valve pad having a second planar surface and containing a second plurality of liquid pathways therethrough which intersect said second planar surface, said first and second planar surfaces of said first and second valve pads slidably engaging each other to enable selected ones of said first plurality of liquid pathways to be moved into and out of liquid flow alignment with selected ones of said second plurality of liquid pathways, said second planar surface having formed therein an open, liquid-retention channel having a volume equal to said prescribed volume, said open, liquid-retention channel being positioned on said second planar surface to be selectively aligned and coupled with (i) a first pair of liquid pathways of said first valve pad during relative sliding movement between said first and second planar surfaces to enable said open, liquid-retention channel to be filled with a sample liquid supplied by a sample liquid source, and (ii) a second pair of liquid pathways of said first valve pad during relative sliding movement between said first and second planar surfaces to enable said prescribed volume of sample liquid contained in said open, liquid-retention channel to be dispensed therefrom by the introduction of a diluent into one of said second pair of liquid pathways.

2. The valve assembly as defined by claim 1 further comprising an external hollow loop fluidly connected with two of said first plurality of pathways, one of said two pathways being the same as one of said first pair of pathways by which said open, liquid-retention channel is filled with liquid, whereby said hollow loop can be filled with said sample liquid in series with said open, liquid-retention channel, said external hollow loop having a prescribed volume which, when added to the volumes of said two pathways, defines a second prescribed volume of sample liquid to be isolated and dispensed by said valve assembly.

3. The valve assembly as defined by claim 2 wherein said external hollow loop is positioned to be selectively aligned and coupled with (i) said two of said first plurality of pathways of said first valve pad during relative sliding movement between said first and second planar surfaces to enable said open, liquid-retention channel to be filled with a sample liquid supplied by a sample liquid source, and (ii) a second pair of liquid pathways of said second valve pad during relative sliding movement between said first and second planar surfaces to enable said prescribed volume of sample liquid contained in said external hollow loop to be dispensed therefrom by the introduction of a second diluent into one of said second pair of liquid pathways of said second valve pad.

4. The valve assembly as defined by claim 2 wherein said external hollow loop is supported by said first valve pad.

5. The valve assembly as defined by claim 1 wherein one of said valve pads is fixed and the other is slidably mounted relative thereto.

6. The valve assembly as defined by claim 1 further comprising a drive mechanism for imparting relative sliding movement between said first and second planar surfaces of said first and second valve pads.

7. The valve assembly as defined by claim 1 further including a housing having an internal cavity configured to support said first valve pad in a fixed position therein, and also supporting said second valve pad for linearly slidable translation with respect to said first planar surface of said first valve pad, and a linear translation actuator arrangement coupled to spaced apart locations of said second valve pad, and being adapted to effect linear translation of said second valve pad with respect to said first planar surface of said first valve pad.

8. The valve assembly as defined by claim 7 wherein said first valve pad is retained in said fixed position by a first portion of said housing and a support element for said linear translation actuator arrangement.

9. The valve assembly as defined by claim 8 wherein said first valve pad is retained in said fixed position by a second portion of said housing and a cover attached to said housing.

10. The valve assembly as defined by claim 8 wherein said second valve pad is supported for pre-aligned linear slidable translation with respect to said first planar surface of said first valve pad by a mechanical biasing structure captured between said cover and said second valve pad.

11. The valve assembly as defined by claim 7 wherein said linear translation actuator arrangement includes a linear actuator supported adjacent to said first portion of said housing and a linear translation device supported adjacent to said second portion of said housing, and wherein said support element for said linear translation actuator arrangement is configured to accommodate linear translation of said second valve pad thereover.

12. The valve assembly as defined by claim 1 wherein said first planar surface of said first valve pad defines a cleaning groove adapted to be ported via a liquid pathway through said first pad to a vacuum source.

13. A dual-pad shear valve assembly for isolating and dispensing a prescribed volume of whole blood in a blood-analyzing instrument, said shear valve assembly comprising:

a first valve pad having a first planar surface and containing a first plurality of liquid pathways therethrough which intersect said first generally planar surface; and

a second valve pad having a second planar surface and containing a second plurality of liquid pathways therethrough which intersect said second planar surface, said second planar surface of said second valve pad slidably engaging said first planar surface of said first valve pad and being adapted to bring selected ones of said first plurality of liquid pathways into liquid flow alignment with selected ones of said second plurality of liquid pathways during sliding movement between said first and second planar surfaces, said second planar surface of said second valve pad having formed therein an open liquid-retention channel having a volume equal to said prescribed volume and being adapted to be coupled with liquid pathways of said first plurality of liquid pathways of said first valve pad, and wherein said first and second valve pads are adapted to be translated relative to one another so as to isolate said open liquid-retention channel of said second valve pad from liquid pathways of said first plurality of liquid pathways of said first valve pad.

14. The valve assembly as defined by claim 13 wherein said first and second valve pads are mounted for relative linear sliding movement.

15. The valve assembly as defined by claim 13 wherein one of said valve pads is supported in a fixed position and the other valve pad is mounted for linear sliding movement relative to said one valve pad.

16. The valve assembly as defined by claim 13 further comprising an external hollow loop fluidly connected with two of said first plurality of pathways, one of said two pathways being used to fill said open liquid-retention channel with whole blood, whereby said hollow loop can be filled with whole blood in series with said open, liquid-retention channel.

17. The valve assembly as defined by claim 16 wherein said external hollow loop has a prescribed volume which, when added to the volumes of said two pathways, defines a second prescribed volume of liquid to be isolated and dispensed by said valve assembly.

18. The valve assembly as defined by claim 16 wherein said external hollow loop is supported by said first valve pad.