Method and compositions for analysis of pentraxin receptors as indicators of disease
First Claim
1. A kit comprising:
- (a) a ligand comprising a pentraxin, (b) a buffer solution containing calcium ions, and (c) an additional ligand that binds to a moiety on particles that is not pentraxin-binding.
1 Assignment
0 Petitions
Accused Products
Abstract
A kit for assessing the level of pentraxin-binding moieties on particles in a biological sample containing a ligand comprising a pentraxin is useful in a method of assessing pentraxin-binding of particles for use in diagnosis of disease or abnormality. The method includes the steps of (a) exposing a biological test sample containing particles that comprise a pentraxin-binding receptor from a test subject to a ligand comprising a pentraxin in the presence of calcium; (b) determining quantitatively the level of binding between particles and ligand in said test sample; and (c) comparing the level of binding in said test sample to the level of binding in a control biological sample containing said particles from a healthy subject of the same species as the subject supplying the test sample. A change in the level of binding in said test sample from that of the control sample is indicative of disease or abnormality.
51 Citations
17 Claims
-
1. A kit comprising:
-
(a) a ligand comprising a pentraxin, (b) a buffer solution containing calcium ions, and (c) an additional ligand that binds to a moiety on particles that is not pentraxin-binding. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
-
-
17. A kit comprising:
-
(a) a ligand comprising a pentraxin, and (b) an additional ligand that binds to a moiety on particles that is not pentraxin-binding.
-
Specification