Biological sealant storage and dispensing system

• US 6,874,657 B2
• Filed: 04/01/2002
• Issued: 04/05/2005
• Est. Priority Date: 04/02/2001
• Status: Expired due to Term

• Current Assignee: CSL Behring GmbH (CSL Limited)
• Original Assignee: ZLB BEHRING GmbH (CSL Limited)
• Inventors: Metzner, Hubert J., Fox, Stewart Madison
• Primary Examiner(s): Mar, Michael
• Assistant Examiner(s): BUECHNER, PATRICK M
• Application Number:
  US10/109,631
• Publication Number:
  US 20020161335A1
• Time in Patent Office: 1,100 Days
• Field of Search: 222/82, 222/88, 222/132, 222/135, 222/137, 222/145.1, 222/145.5, 222/326, 222/327, 222/386, 222/391, 433/90
• US Class Current: 222/82
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 2017/00495 for two-component glue
• CPC Class Codes: A61P 7/04 Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Abstract

A method for dispensing a bilogical sealant and a dispensing system for dispensing the biological sealant are described. The dispensing system comprises a dispenser and a plurality of cartridge for delivering a biological sealant to an application site. The sealant is presented as a multi-component liquid sealant, with each component contained in a cartridge comprising a tubular body closed at one end with a pierceable seal and closed at the other end by a piston element movable axially within the tubular body. The dispenser coprises a plurality of recesses to receive respective cartridges containing the components of the sealant. Each recess includes means to establish a fluid connection with the cartridge placed within the recess. The dispenser further comprises means for engaging the piston elements of the cartridges to move the piston element axially so as to expel the sealant components. Ducting within the dispenser leads the sealant components to a dispensing point.

Claims

1. An apparatus for dispensing a multi-component biological sealant, comprising:

a plurality of sealant cartridges for containing respective components of the sealant, each sealant cartridge including a substantially tubular body having a first end closed by a seal and a second end sealed by an axially-movable piston element; and

a dispenser for dispensing the sealant components from the cartridges, the dispenser comprising;

a main body having a plurality of elongated recesses for receiving respective cartridges;

means for establishing fluid connection with said first end of the cartridge associated with each recess;

ducting means for transporting respective components of the sealant from said cartridges to a dispensing point;

means for engaging the piston elements to move the piston elements axially towards said first ends of their respective cartriges; and

a drive mechanism connected to the means for engaging the piston elements and configured to assist in moving the means for engaging the piston elements.

2. An apparatus according to claim 1, wherein the seal closing each cartridge at its first end is a pierceable septum, and the means for establishing fluid connection comprises a non-coring needle.

3. An apparatus according to claim 1, wherein each cartridge has a Luer connection at its first end, and the means for establishing fluid connection comprises a complementary Luer connection.

4. An apparatus according to claim 1, wherein the means for engaging the piston elements comprises a drive plate including a plurality of push rods, each of the push rods configured to engage a respective piston element.

5. An apparatus according to claim 4, wherein the drive plate has an elongate guide element receivable in a guide recess in the main body of the dispenser for guiding movement of the drive plate.

6. An apparatus according to claim 1, wherein the means for establishing fluid connection with said first end of a cartridge and associated with each recess is located in each recess of the dispenser and are each independently connected to the dispensing point by a respective duct.

7. An apparatus according to claim 6, wherein the dispensing point comprises a single Luer connection connected to all of the recesses.

8. An apparatus according to claim 6, wherein the dispensing point comprises a first Luer connection connected to one of the recesses, and a second Luer connection connected to one or more of the remaining recesses.

9. An apparatus according to claim 1, wherein the cartridges are formed from transparent material, and wherein windows are formed in the body of the dispenser so that the amount of material present in a cartridge within a recess of the dispenser body may be visually determined.

10. An apparatus according to claim 1, wherein the cartridges for respective components of the sealant are of substantially equal axial length, and wherein the cartridges each have a different cross-sectional area.

11. An apparatus according to claim 1, wherein the cartridges have a substantially circular cross-section.

12. An apparatus according to claim 1, wherein the cartridges each have a differently shaped cross-section, and wherein the recesses in the dispenser body are each shaped to correspond with a respective one of the cross-sectional shapes of the cartridges.

13. A cartridge for use in the apparatus of claim 1, comprising a substantially tubular body having a first end closed by a pierceable seal and a second end sealed by an axially-movable piston element, and further comprising a component of a biological sealant contained between the pierceable seal and the piston element.

14. An apparatus for dispensing a multi-component biological sealant, comprising:

a plurality of sealant cartridges for containing respective components of the sealant, each sealant cartridge including a substantially tubular body having a first end closed by a seal and a second end sealed by an axially-movable piston element; and

a dispenser for dispensing the sealant components from the cartridges, the dispenser comprising;

a main body having a plurality of elongated recesses for receiving respective cartridges;

means for establishing fluid connection with said first end of the cartridge associated with each recess;

ducting means for transporting respective components of the sealant from said cartridges to a dispensing point; and

means for engaging the piston elements to move the piston elements axially towards said first ends of their respective cartridges, wherein the means for engaging the piston elements comprises a drive plate including a plurality of push rods, each of the push rods configured to engage a respective piston element,

wherein the main body of the dispenser includes a drive mechanism cooperable with the drive plate to move the drive plate in the axial direction toward the recesses.

15. An apparatus according to claim 14, wherein the drive mechanism is disengageable from the drive plate to permit movement of the drive plate in the axial direction away from the recesses.

16. An apparatus according to claim 14, wherein the main body of the dispenser includes a pawl and the drive plate comprises a ratchet, the pawl being engageable with the ratchet to move the drive plate toward the recesses.

17. An apparatus for dispensing a multi-component biological sealant, comprising:

a plurality of sealant cartridges for containing respective components of the sealant, each sealant cartridge including a substantially tubular body having a first end closed by a seal and a second end sealed by an axially-movable piston element; and

a dispenser for dispensing the sealant components from the cartridges, the dispenser comprising;

a main body having a plurality of elongated recesses for receiving respective cartridges;

means for establishing fluid connection with said first end of the cartridge associated with each recess;

ducting means for transporting respective components of the sealant from said cartridges to a dispensing point; and

means for engaging the piston elements to move the piston elements axially towards said first ends of their respective cartridges,

wherein three recesses are provided in the dispenser to accommodate cartridges containing three components of a biological sealant, and wherein the means for establishing fluid connection and associated with two of the recesses have first and second cartridges located therein are connected to the dispensing point by a common duct, and wherein the means for establishing fluid connection and associated with the third recess have a third cartridge connected to the dispensing point by a separate duct.

18. An apparatus according to claim 17, wherein said dispenser includes a mixing chamber to receive components of the biological sealant from cartridges in said two recesses, and to supply a mixture of the two components to the common duct.

19. An apparatus according to claim 17, wherein the dispensing point comprises a first Luer connection at which the common duct opens, and a second Luer connection at which the separate duct opens.

20. An apparatus according to claim 19, wherein the first and second Luer connections comprise a conical central portion and an internally-threaded collar axially retained in relation to the conical central portion and rotatable relative thereto.

21. A dispenser for use in an apparatus for dispensing a biological sealant having multiple sealant components, each of the sealant components being contained in a cartridge having a substantially tubular body with a first end closed by a pierceable seal and a second end sealed by an axially-movable piston element, wherein the dispenser comprises:

a main body having a plurality of elongated recesses for receiving respective cartridges containing the respective sealant components and a dispensing point for delivering the sealant components;

means for establishing fluid connection with said first end of the cartridge associated with each recess;

ducting means for transporting respective components of the sealant from said cartridges to the dispensing point;

means for engaging the piston elements to move the piston elements axially towards said first ends of their respective and cartridges; and

a drive mechanism connected to the means for engaging the piston elements and configured to assist in moving the means for engaging the piston elements.

22. A dispenser according to claim 21, wherein the means for establishing fluid connection comprises a non-coring needle.

23. A dispenser according to claim 21, wherein the means for establishing fluid connection comprises a Luer connection.

24. A dispenser according to claim 21, wherein the means for engaging the piston elements comprises a drive plate including a plurality of push rods, each of the push rods configured to engage a respective piston element.

25. A dispenser according to claim 24, wherein the drive plate has an elongate guide element receivable in a guide recess in the main body of the dispenser for guiding movement of the drive plate.

26. A dispenser according to claim 21, wherein each recess is independently connected to the dispensing point by a separate duct.

27. A dispenser according to claim 21, wherein the dispensing point comprises a single Luer connection connected to all of the recesses.

28. A dispenser according to claim 21, wherein the dispensing point comprises a first Luer connection connected to one of the recesses, and a second Luer connection connected to at least one of the remaining recesses.

29. A dispenser according to claim 28, wherein the main body includes three recesses to accommodate three cartridges, each cartridge containing one of three components of a biological sealant, and wherein two of the recesses of the dispenser are connected to the dispensing point by a common duct, and the third recess is connected to the dispensing point by a separate duct.

30. A dispenser according to claim 29, further comprising a mixing chamber having respective inlets connected to said two recesses, and an outlet connected to the common duct.

31. A dispenser according to claim 29, wherein the dispensing point comprises a first Luer connection at which the common duct opens, and a second Luer connection at which the separate duct opens.

32. A dispenser according to claim 31, wherein at least one of the first and second Luer connections comprises a conical central portion and an internally-threaded collar axially retained in relation to the conical central portion and rotatable relative thereto.

33. A dispenser according to claim 32, wherein the first and second Luer connections comprise a conical central portion and an internally-threaded collar axially retained in relation to the conical central portion and rotatable relative thereto.

34. A dispenser for use in an apparatus for dispensing a biological sealant having multiple sealant components, each of the sealant components being contained in a cartridge having a substantially tubular body with a first end closed by a pierceable seal and a second end sealed by an axially-movable piston element, wherein the dispenser comprises:

a main body having a plurality of elongated recesses for receiving respective cartridges containing the respective sealant components and a dispensing point for delivering the sealant components;

means for establishing fluid connection with said first end of the cartridge associated with each recess;

ducting means for transporting respective components of the sealant from said cartridges to the dispensing point; and

means for engaging the piston elements to move the piston elements axially towards said first ends of their respective cartridges,

wherein the means for engaging the piston elements comprises a drive plate including a plurality of push rods, each of the push rods configured to engage a respective piston element,

wherein the main body of the dispenser comprises a drive mechanism cooperable with the drive plate to move the drive plate in the axial direction toward the recesses.

35. A dispenser according to claim 34, wherein the drive mechanism is disengageable from the drive plate to permit movement of the drive plate in the axial direction away from the recesses.

36. A dispenser according to claim 34, wherein the main body of the dispenser includes a pawl and the drive plate comprises a ratchet, the pawl being engageable with the ratchet to move the drive plate toward the recesses.

37. An apparatus for dispensing a multi-component biological sealant, comprising:

a plurality of sealant cartridges for containing respective components of the sealant, each sealant cartridge including a substantially tubular body having a first end closed by a seal and a second end sealed by an axially-movable piston element; and

a dispenser for dispensing the sealant components from the cartridges, the dispenser comprising;

a main body having a plurality of elongated recesses for receiving respective cartridges;

means for establishing fluid connection with said first end of the cartridge associated with each recess;

ducting means for transporting respective components of the sealant from said cartridges to a dispensing point; and

means for engaging the piston elements to move the piston elements axially towards said first ends of their respective cartridges,

wherein three recesses are provided in the dispenser to accommodate cartridges containing three components of a biological sealant.

38. An apparatus according to claim 37, wherein the means for establishing fluid connection and associated with two of the recesses have first and second cartridges located therein are connected to the dispensing point by a common duct.

39. An apparatus according to claim 38, wherein the means for establishing fluid connection and associated with the third recess have a third cartridge connected to the dispensing point by a separate duct.